dc.creator | Ríos Moreno, María José | es |
dc.creator | Galera Ruiz, Hugo | es |
dc.creator | Miguel Rodríguez, Manuel de | es |
dc.creator | Carmona López, María Inés | es |
dc.creator | Illanes, Matilde | es |
dc.creator | Galera Davidson, Hugo | es |
dc.date.accessioned | 2023-02-07T15:07:05Z | |
dc.date.available | 2023-02-07T15:07:05Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Ríos Moreno, M.J., Galera Ruiz, H., Miguel Rodríguez, M.d., Carmona López, M.I., Illanes, M. y Galera Davidson, H. (2011). Inmunohistochemical Profile of Solid Cell Nest of Thyroid Gland. ENDOCRINE PATHOLOGY, 22 (1), 35-39. https://doi.org/10.1007/s12022-010-9145-4. | |
dc.identifier.issn | 1046-3976 | es |
dc.identifier.issn | 1559-0097 | es |
dc.identifier.uri | https://hdl.handle.net/11441/142516 | |
dc.description.abstract | It It is widely held that solid cell nests (SCN) of the
thyroid are ultimobranchial body remnants. SCNs are
composed of main cells and C cells. It has been suggested
that main cells might be pluripotent cells contributing to the
histogenesis of C cells and follicular cells, as well as to the
formation of certain thyroid tumors. The present study
sought to analyze the immunohistochemical profile of SCN
and to investigate the potential stem cell role of SCN main
cells. Tissue sections from ten cases of nodular hyperplasia
(non-tumor goiter) with SCNs were retrieved from the files
of the Hospital Infanta Luisa (Seville, Spain). Parathormone
(PTH), calcitonin (CT), thyroglobulin (TG), thyroid tran scription factor (TTF-1), galectin 3 (GAL3), cytokeratin 19
(CK 19), p63, bcl-2, OCT4, and SALL4 expression were
evaluated by immunohistochemistry. Patient clinical data
were collected, and tissue sections were stained with
hematoxylin–eosin for histological examination. Most cells
stained negative for PTH, CT, TG, and TTF-1. Some cells
staining positive for TTF-1 and CT required discussion.
However, bcl-2, p63, GAL3, and CK 19 protein expression
was detected in main cells. OCT4 protein expression was
detected in only two cases, and SALL4 expression in none.
Positive staining for bcl-2 and p63, and negative staining
for PTH, CT, and TG in SCN main cells are both consistent
with the widely accepted minimalist definition of stem
cells, thus supporting the hypothesis that they may play a
stem cell role in the thyroid gland, although further research
will be required into stem cell markers. Furthermore, p63
and GAL-3 staining provides a much more sensitive means
of detecting SCNs than staining for carcinoembryonic
antigen, calcitonin, or other markers; this may help to
distinguish SCNs from their mimics. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | Humana Press Inc. | es |
dc.relation.ispartof | ENDOCRINE PATHOLOGY, 22 (1), 35-39. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Solid cell nests | es |
dc.subject | Main cells | es |
dc.subject | Stem cells | es |
dc.subject | P63 | es |
dc.title | Inmunohistochemical Profile of Solid Cell Nest of Thyroid Gland | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s12022-010-9145-4 | es |
dc.identifier.doi | 10.1007/s12022-010-9145-4 | es |
dc.journaltitle | ENDOCRINE PATHOLOGY | es |
dc.publication.volumen | 22 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 35 | es |
dc.publication.endPage | 39 | es |