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dc.creatorGómez-Regalado, María del Carmenes
dc.creatorMartín Bueno, Juliaes
dc.creatorSantos Morcillo, Juan Luises
dc.creatorAparicio Gómez, Irenees
dc.creatorAlonso Álvarez, Estebanes
dc.creatorZafra-Gómez, Albertoes
dc.date.accessioned2023-01-23T11:38:59Z
dc.date.available2023-01-23T11:38:59Z
dc.date.issued2023-02
dc.identifier.citationGómez-Regalado, M.d.C., Martín Bueno, J., Santos Morcillo, J.L., Aparicio Gómez, I., Alonso Álvarez, E. y Zafra-Gómez, A. (2023). Bioaccumulation/bioconcentration of pharmaceutical active compounds in aquatic organisms: Assessment and factors database. Science of The Total Environment, 861 (February), 160638. https://doi.org/10.1016/j.scitotenv.2022.160638.
dc.identifier.issn0048-9697es
dc.identifier.issn1879-1026es
dc.identifier.urihttps://hdl.handle.net/11441/141714
dc.description.abstractThere is increasing evidence that the presence of certain pharmaceuticals in the environment leads to biota exposure and constitute a potential risk for ecosystems. Bioaccumulation is an essential focus of risk assessment to evaluate at what degree emerging contaminants are a hazard both to the environment and the individuals that inhabit it. The main goals of the present review are 1) to summarize and describe the research and factors that should be taken into account in the evaluation of bioaccumulation of pharmaceuticals in aquatic organisms; and 2) to provide a database and a critical review of the bioaccumulation/bioconcentration factors (BAF or BCF) of these compounds in organisms of different trophic levels. Most studies fall into one of two categories: laboratory-scale absorption and purification tests or field studies and, to a lesser extent, large-scale, semi-natural system tests. Although in the last 5 years there has been considerable progress in this field, especially in species of fish and molluscs, research is still limited on other aquatic species like crustaceans or algae. This revision includes >230 bioconcentration factors (BCF) and >530 bioaccumulation factors (BAF), determined for 113 pharmaceuticals. The most commonly studied is the antidepressant group, followed by diclofenac and carbamazepine. There is currently no reported accumulation data on certain compounds, such as anti-cancer drugs. BCFs are highly influenced by experimental factors (notably the exposure level, time or temperature). Field BAFs are superior to laboratory BCFs, highlighting the importance of field studies for reliable assessments and in true environmental conditions. BAF data appears to be organ, species and compound-specific. The potential impact on food web transfer is also considered. Among different aquatic species, lower trophic levels and benthic organisms exhibit relatively higher uptake of these compounds.es
dc.formatapplication/pdfes
dc.format.extent39 p.es
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofScience of The Total Environment, 861 (February), 160638.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBioaccumulation factores
dc.subjectBioconcentration factores
dc.subjectBiotaes
dc.subjectEmerging pollutantses
dc.subjectExposurees
dc.titleBioaccumulation/bioconcentration of pharmaceutical active compounds in aquatic organisms: Assessment and factors databasees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Analíticaes
dc.relation.projectIDPID2020-117641RB-I00es
dc.relation.projectIDB.RNM.362.UGR20es
dc.relation.projectIDP20_00556es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0048969722077415?via%3Dihubes
dc.identifier.doi10.1016/j.scitotenv.2022.160638es
dc.contributor.groupUniversidad de Sevilla. FQM344: Análisis Químico Industrial y Medioambientales
dc.journaltitleScience of The Total Environmentes
dc.publication.volumen861es
dc.publication.issueFebruaryes
dc.publication.initialPage160638es
dc.contributor.funderMCIN/AEI/10.13039/501100011033 grant PID2020-117641RB-I00es
dc.contributor.funderConsejería de Economía, Conocimiento, Empresas y Universidad (Spanish regional Government of Andalucia) including European funding from ERDF 2014–2020 program, grant B.RNM.362.UGR20es
dc.contributor.funderConsejería de Economía, Conocimiento, Empresas y Universidad (Spanish regional Government of Andalucia) including European funding from ERDF 2014–2020 program, grant P20_00556es

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