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dc.creatorMorilla Romero de la Osa, Rubénes
dc.creatorMedrano Ortega, Francisco Javieres
dc.creatorCalzada, Anaes
dc.creatorQuintana, Estheres
dc.creatorCampano, Elenaes
dc.creatorFriaza, Vicentees
dc.creatorCalderón Sandubete, Enrique Josées
dc.creatorHorra Padilla, Carmen de laes
dc.date.accessioned2023-01-10T14:32:13Z
dc.date.available2023-01-10T14:32:13Z
dc.date.issued2021-03-10
dc.identifier.citationMorilla Romero de la Osa, R., Medrano Ortega, F.J., Calzada, A., Quintana, E., Campano, E., Friaza, V.,...,Horra Padilla, C.d.l. (2021). Pneumocystis jirovecii among patients with cystic fibrosis and their household members. Medical Mycology, 59 (9), 849-854. https://doi.org/10.1093/mmy/myab010.
dc.identifier.issn1369-3786;1460-2709es
dc.identifier.urihttps://hdl.handle.net/11441/141093
dc.description.abstractWe conducted a pilot study of patients with cystic fibrosis (CF) to assess intra-family transmission of P. jirovecii and compare it with data on other prevalent pathogens such as P. aeruginosa and S. pneumoniae, in which respiratory transmission has already been documented. Oral swab samples from 10 patients with CF and 15 household members were collected at baseline and 2 weeks later. P. aeruginosa and S. pneumoniae were assessed using standardized culture methods and PCR, and P. jirovecii was assessed using real and nested PCR, genotyping the positive samples by direct sequencing. P. aeruginosa cultures were positive for 7/10 (70%) of patients with CF at baseline and was identified by PCR in 8/10 (80%) of cases at baseline and 2 weeks later. S. pneumoniae cultures were negative for all patients, but the microorganism was identified by PCR in two cases. P. jirovecii was detected by real time and nested PCR in 5/10 (50%) of the patients at the two time points. In the household members, P. aeruginosa and P. jirovecii were identified in 7/15 (46.7%), and S. pneumoniae was identified in 8/15 (53,3%). The concordance of positive or negative pairs of patients with CF and their household members was 33.3% (5/15) for P. aeruginosa, 46.7% (7/15) for S. pneumonia and 93.3% (14/15) for P. jirovecii. The concordance for P. jirovecii genotypes among five pairs with available genotype was 100%. This study suggests for the first time the possible transmission of Pneumocystis in the home of patients with CF, indicating that patients and their household members are reservoirs and possible sources of infection.es
dc.formatapplication/pdfes
dc.format.extent6 p.es
dc.language.isoenges
dc.publisherOxford University Presses
dc.relation.ispartofMedical Mycology, 59 (9), 849-854.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPneumocystis jiroveciies
dc.subjectdisease transmissiones
dc.subjectcystic fibrosises
dc.subjectpolymerase chain reactiones
dc.titlePneumocystis jirovecii among patients with cystic fibrosis and their household memberses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Enfermeríaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.projectIDCYTED 212RT0450es
dc.relation.publisherversionhttps://academic.oup.com/mmy/article/59/9/849/6166790es
dc.identifier.doi10.1093/mmy/myab010es
dc.journaltitleMedical Mycologyes
dc.publication.volumen59es
dc.publication.issue9es
dc.publication.initialPage849es
dc.publication.endPage854es
dc.contributor.funderRed Iberoamericana sobre Pneumocistosises

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