dc.creator | Jiménez Cortegana, Carlos | es |
dc.creator | García-Galey, Alba | es |
dc.creator | Tami, Malika | es |
dc.creator | Pino, Pilar del | es |
dc.creator | Carmona, Isabel | es |
dc.creator | López Enriquez, Soledad | es |
dc.creator | Alba Jiménez, Gonzalo | es |
dc.creator | Sánchez Margalet, Víctor | es |
dc.date.accessioned | 2022-11-15T16:02:44Z | |
dc.date.available | 2022-11-15T16:02:44Z | |
dc.date.issued | 2021-06-30 | |
dc.identifier.citation | Jiménez Cortegana, C., García-Galey, A., Tami, M., Pino, P.d., Carmona, I., López Enriquez, S.,...,Sánchez Margalet, V. (2021). Role of leptin in non-alcoholic fatty liver disease. Biomedicines, 9 (7), 762. https://doi.org/10.3390/biomedicines9070762. | |
dc.identifier.issn | 2227-9059 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139454 | |
dc.description.abstract | Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global
population, poses a substantial health and economic burden in all countries, yet there is no approved
pharmacotherapy to treat this entity, nor well-established strategies for its diagnosis. Its prevalence
has been rapidly driven by increased physical inactivity, in addition to excessive calorie intake
compared to energy expenditure, affecting both adults and children. The increase in the number of
cases, together with the higher morbimortality that this disease entails with respect to the general
population, makes NAFLD a serious public health problem. Closely related to the development
of this disease, there is a hormone derived from adipocytes, leptin, which is involved in energy
homeostasis and lipid metabolism. Numerous studies have verified the relationship between persistent hyperleptinemia and the development of steatosis, fibrinogenesis and liver carcinogenesis.
Therefore, further studies of the role of leptin in the NAFLD spectrum could represent an advance in
the management of this set of diseases. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Biomedicines, 9 (7), 762. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Fatty liver | es |
dc.subject | Steatohepatitis | es |
dc.subject | Obesity | es |
dc.subject | Metabolic syndrome | es |
dc.subject | Leptin | es |
dc.title | Role of leptin in non-alcoholic fatty liver disease | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.publisherversion | https://www.mdpi.com/2227-9059/9/7/762 | es |
dc.identifier.doi | 10.3390/biomedicines9070762 | es |
dc.journaltitle | Biomedicines | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | 762 | es |