Artículo
Prevalence and risk factors for multidrug-resistant organisms colonization in long-term care facilities around the world: a review
Autor/es | Rodríguez Villodres, Ángel
Martín-Gandul, Cecilia Peñalva, Germán Guisado Gil, Ana Belén Crespo-Rivas, Juan Carlos Pachón Ibáñez, María Eugenia Lepe Jiménez, José Antonio Cisneros, José Miguel |
Departamento | Universidad de Sevilla. Departamento de Microbiología Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021-06-07 |
Fecha de depósito | 2022-11-15 |
Publicado en |
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Resumen | Elderly people confined to chronic care facilities face an increased risk of acquiring infections by multidrug-resistant organisms (MDROs). This review presents the current knowledge of the prevalence and risk factors for ... Elderly people confined to chronic care facilities face an increased risk of acquiring infections by multidrug-resistant organisms (MDROs). This review presents the current knowledge of the prevalence and risk factors for colonization by MDROs in long-term care facilities (LTCF), thereby providing a useful reference to establish objectives for implementing successful antimicrobial stewardship programs (ASPs). We searched in PubMed and Scopus for studies examining the prevalence of MDROs and/or risk factors for the acquisition of MDROs in LTCF. One hundred and thirty-four studies published from 1987 to 2020 were included. The prevalence of MDROs in LTCF varies between the different continents, where Asia reported the highest prevalence of extended-spectrum ß-lactamase (ESBL) Enterobacterales (71.6%), carbapenem resistant (CR) Enterobacterales (6.9%) and methicillin-resistant Staphylococcus aureus (MRSA) (25.6%) and North America the highest prevalence to MDR Pseudomonas aeruginosa (5.4%), MDR Acinetobacter baumannii (15.0%), vancomycin-resistant Enterococcus spp. (VRE) (4.0%), and Clostridioides difficile (26.1%). Furthermore, MDRO prevalence has experienced changes over time, with increases in MDR P. aeruginosa and extended spectrum ß-lactamase producing Enterobacterales observed starting in 2015 and decreases of CR Enterobacterales, MDR A. baumannii, VRE, MRSA and C. difficile. Several risk factors have been found, such as male sex, chronic wounds, the use of medical devices, and previous antibiotic use. The last of these aspects represents one of the most important modifiable factors for reducing colonization with MDROs through implementing ASPs in LTCF. |
Agencias financiadoras | European Development Regional Fund 'A way to achieve Europe' ERDF, Spanish Network for the Research in Infectious Diseases, REIPI RD16/0016/0009 European Development Regional Fund "A way to achieve Europe" European Development Regional Fund "A way to achieve Europe", Operative program Intelligent Growth 2014-2020 Instituto de Salud Carlos III, PI17-02195 Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad, Spanish Network for Research in Infectious Diseases, REIPI RD16/0016/0001 Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de InvestigacionCooperativa, Ministry of Economy, Industry and Competitiveness, Spanish Network for Research in Infectious Diseases, REIPI RD16/0016/0001; RD16/0016/0009 Instituto de Salud Carlos III, the Spanish Ministry of Economy, Industry, and Competitiveness, PI17-02195 Plan Nacional de I+D+i 2013-2016 Servicio Andaluz de Salud, Junta de Andalucia, Spain, C1-0038-2019 Subprograma Rio Hortega, Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Ciencia, Innovacion y Universidades, Spain |
Identificador del proyecto | CM18/00122
CM19/00029 REIPI RD16/0016/0009 PI17-02195 REIPI RD16/0016/0001 RD16/0016/0009 |
Cita | Rodríguez-Villodres, Á., Martín-Gandul, C., Peñalva, G., Guisado-Gil, A.B., Crespo-Rivas, J.C., Pachón-Ibáñez, M.E.,...,Cisneros, J.M. (2021). Prevalence and risk factors for multidrug-resistant organisms colonization in long-term care facilities around the world: a review. Antibiotics, 10 (6). https://doi.org/10.3390/antibiotics10060680. |
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