dc.creator | Sanegre, Sabina | es |
dc.creator | Eritja, Núria | es |
dc.creator | Andrea, Carlos de | es |
dc.creator | Díaz-Martín, Juan | es |
dc.creator | Díaz-Lagares, Ángel | es |
dc.creator | Jácome, María Amalia | es |
dc.creator | Salguero-Aranda, Carmen | es |
dc.creator | Álava Casado, Enrique de | |
dc.creator | Noguera, Rosa | |
dc.date.accessioned | 2022-11-09T10:27:41Z | |
dc.date.available | 2022-11-09T10:27:41Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Sanegre, S., Eritja, N., Andrea, C.d., Díaz-Martín, J., Díaz-Lagares, Á., Jácome, M.A. y Salguero-Aranda, C. (2021). Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.670185. | |
dc.identifier.issn | 2296-634X(electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/139150 | |
dc.description.abstract | The invasive tumor front (the tumor–host interface) is vitally important in malignant
cell progression and metastasis. Tumor cell interactions with resident and infiltrating
host cells and with the surrounding extracellular matrix and secreted factors ultimately
determine the fate of the tumor. Herein we focus on the invasive tumor front,
making an in-depth characterization of reticular fiber scaffolding, infiltrating immune
cells, gene expression, and epigenetic profiles of classified aggressive primary uterine
adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-
fixed samples before and after microdissection were scanned and studied. Reticular
fiber architecture and immune cell infiltration were analyzed by automatized algorithms
in colocalized regions of interest. Despite morphometric resemblance between reticular
fibers and high presence of macrophages, we found some variance in other immune
cell populations and distinctive gene expression and cell adhesion-related methylation
signatures. Although no evident overall differences in immune response were detected
at the gene expression and methylation level, impaired antimicrobial humoral response
might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive
tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the
use of common biomarkers and therapies. Furthermore, molecular and architectural
characterization of the invasive front of uterine malignancies may provide additional
prognostic information beyond established prognostic factors. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.relation.ispartof | Frontiers in Cell and Developmental Biology, 9. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Tumor-host interface | es |
dc.subject | Tumor microenvironment | es |
dc.subject | Extracellular matrix | es |
dc.subject | Reticular fibers | es |
dc.subject | Immune cells | es |
dc.subject | Gene expression | es |
dc.subject | Epigenetic profiles | es |
dc.title | Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.relation.projectID | JR17/00016 | es |
dc.relation.projectID | CB16/12/00484 | es |
dc.relation.projectID | CB16/12/0328 | es |
dc.relation.projectID | CB16/12/00363 | es |
dc.relation.projectID | CB16/12/00481 | es |
dc.relation.projectID | CB16/12/00231 | es |
dc.relation.projectID | ERDF, PI17/01558 | es |
dc.relation.projectID | PI20/01107 | es |
dc.relation.projectID | CB16/12/00364 | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fcell.2021.670185/full | es |
dc.identifier.doi | 10.3389/fcell.2021.670185 | es |
dc.journaltitle | Frontiers in Cell and Developmental Biology | es |
dc.publication.volumen | 9 | es |
dc.contributor.funder | "Juan Rodes" from the ISCIII, JR17/00016 | es |
dc.contributor.funder | CIBERONC, CB16/12/00484; CB16/12/0328; CB16/12/00363; CB16/12/00364; CB16/12/00481; CB16/12/00231 | es |
dc.contributor.funder | ERDF, PI17/01558; PI20/01107 | es |
dc.contributor.funder | Grupos Coordinados Estables from the Asociacion Espanola Contra el Cancer (AECC) | es |
dc.contributor.funder | ISCIII, PI17/01558; PI20/01107 | es |
dc.contributor.funder | CB16/12/00364 | es |