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dc.creatorTessier, Sarahes
dc.creatorFerhi, Omares
dc.creatorGeoffroy, Marie-Claudees
dc.creatorGonzález Prieto, Románes
dc.creatorCanat, Antoinees
dc.creatorQuentin, Samueles
dc.creatorPla, Marikaes
dc.creatorNiwa-Kawakita, Michikoes
dc.creatorBercier, Pierrees
dc.creatorRerolle, Domitillees
dc.creatorTherizols, Pierrees
dc.creatorFabre, Emmanuellees
dc.creatorVertegaal, Alfred C. O.es
dc.creatorde Thé, Hugueses
dc.creatorLallemand-Breitenbach, Valeriees
dc.date.accessioned2022-10-14T14:16:56Z
dc.date.available2022-10-14T14:16:56Z
dc.date.issued2022
dc.identifier.citationTessier, S., Ferhi, O., Geoffroy, M., González Prieto, R., Canat, A., Quentin, S.,...,Lallemand-Breitenbach, V. (2022). Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells. Nature Communications, 13 (1), 5726. https://doi.org/10.1038/s41467-022-33147-6.
dc.identifier.issn2041-1723es
dc.identifier.urihttps://hdl.handle.net/11441/137921
dc.description.abstractMembrane-less organelles are condensates formed by phase separation whose functions often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to regulate senescence or metabolic adaptation. PML NBs recruit many partner proteins, but the actual biochemical mechanism underlying their pleiotropic functions remains elusive. Similarly, PML role in embryonic stem cell (ESC) and retro-element biology is unsettled. Here we demonstrate that PML is essential for oxidative stress-driven partner SUMO2/3 conjugation in mouse ESCs (mESCs) or leukemia, a process often followed by their poly-ubiquitination and degradation. Functionally, PML is required for stress responses in mESCs. Differential proteomics unravel the KAP1 complex as a PML NB-dependent SUMO2-target in arsenic-treated APL mice or mESCs. PML-driven KAP1 sumoylation enables activation of this key epigenetic repressor implicated in retro-element silencing. Accordingly, Pml−/− mESCs re-express transposable elements and display 2-Cell-Like features, the latter enforced by PML-controlled SUMO2-conjugation of DPPA2. Thus, PML orchestrates mESC state by coordinating SUMO2-conjugation of different transcriptional regulators, raising new hypotheses about PML roles in cancer.es
dc.formatapplication/pdfes
dc.format.extent15 p.es
dc.language.isoenges
dc.publisherSpringer Naturees
dc.relation.ispartofNature Communications, 13 (1), 5726.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleExploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cellses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
dc.relation.publisherversionhttps://doi.org/10.1038/s41467-022-33147-6es
dc.identifier.doi10.1038/s41467-022-33147-6es
dc.journaltitleNature Communicationses
dc.publication.volumen13es
dc.publication.issue1es
dc.publication.initialPage5726es

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