Artículo
Cortical thickness across the lifespan: Data from 17,075healthy individuals aged 3–90 years
Autor/es | Frangou, Sophia
Modabbernia, Amirhossein Williams, Steven C.R. Papachristou, Efstathios Doucet, Gaelle E. Agartz, Ingrid Crespo Facorro, Benedicto Kanai, Ryota |
Departamento | Universidad de Sevilla. Departamento de Psiquiatría |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-10-03 |
Publicado en |
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Resumen | Delineating the association of age and cortical thickness in healthy individuals is criti-cal given the association of cortical thickness with cognition and behavior. Previousresearch has shown that robust estimates of the ... Delineating the association of age and cortical thickness in healthy individuals is criti-cal given the association of cortical thickness with cognition and behavior. Previousresearch has shown that robust estimates of the association between age and brainmorphometry require large-scale studies. In response, we used cross-sectional datafrom 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Geneticsthrough Meta-Analysis (ENIGMA) Consortium to infer age-related changes in corticalthickness. We used fractional polynomial (FP) regression to quantify the associationbetween age and cortical thickness, and we computed normalized growth centilesusing the parametric Lambda, Mu, and Sigma method. Interindividual variability wasestimated using meta-analysis and one-way analysis of variance. For most regions,their highest cortical thickness value was observed in childhood. Age and corticalthickness showed a negative association; the slope was steeper up to the thirddecade of life and more gradual thereafter; notable exceptions to this general patternwere entorhinal, temporopolar, and anterior cingulate cortices. Interindividual vari-ability was largest in temporal and frontal regions across the lifespan. Age and its FPcombinations explained up to 59% variance in cortical thickness. These results mayform the basis of further investigation on normative deviation in cortical thicknessand its significance for behavioral and cognitive outcomes. |
Identificador del proyecto | PI020499
PI050427 PI060507 PI14/00639 PI14/00918 |
Cita | Frangou, S., Modabbernia, A., Williams, S.C.R., Papachristou, E., Doucet, G.E., Agartz, I.,...,Kanai, R. (2021). Cortical thickness across the lifespan: Data from 17,075healthy individuals aged 3–90 years. Human Brain Mapping, 43 (1), 431-451. https://10.1002/hbm.25364. |
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