dc.creator | Delvecchio, Giuseppe | es |
dc.creator | Maggioni, Eleonora | es |
dc.creator | Pigoni, Alessandro | es |
dc.creator | Crespo Facorro, Benedicto | es |
dc.creator | Nenadić, Igor | es |
dc.creator | Benedetti, Francesco | es |
dc.creator | Gaser, Christian | es |
dc.creator | Sauer, Heinrich | es |
dc.creator | Roiz-Santiañez, Roberto | es |
dc.creator | Poletti, Sara | es |
dc.creator | Rossetti, Maria G. | es |
dc.creator | Bellani, Marcella | es |
dc.creator | Perlini, Cinzia | es |
dc.creator | Ruggeri, Mirella | es |
dc.creator | Diwadkar, Vaibhav A. | es |
dc.creator | Brambilla, Paolo | es |
dc.date.accessioned | 2022-10-03T07:48:56Z | |
dc.date.available | 2022-10-03T07:48:56Z | |
dc.date.issued | 2021-02-05 | |
dc.identifier.citation | Delvecchio, G., Maggioni, E., Pigoni, A., Crespo Facorro, B., Nenadić, I., Benedetti, F.,...,Brambilla, P. (2021). Sexual regional dimorphism of post-adolescent and middle age brain maturation. A multi-center 3T MRI study. Frontiers In Aging Neuroscience, 13 | |
dc.identifier.issn | 1663-4365 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137548 | |
dc.description.abstract | Sex-related differences are tied into neurodevelopmental and lifespan processes,
beginning early in the perinatal and developmental phases and continue into adulthood.
The present study was designed to investigate sexual dimorphism of changes in gray
matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood
using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the
European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT).
Three hundred and seventy three subjects underwent a 3.0 T MRI session across
four European Centers. Age by sex effects on GM volumes were investigated using
voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions
(ROI). Females and males showed overlapping and non-overlapping patterns of GM
volume changes during aging. Overlapping age-related changes emerged in bilateral
frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed
non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral
mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These
findings highlight the importance of accounting for sex differences in cross-sectional
analyses, not only in the study of normative changes, but particularly in the context
of psychiatric and neurologic disorders, wherein sex effects may be confounded with
disease-related changes. | es |
dc.description.sponsorship | Ministry of Health, GR-2018-12367789 to EM, RF-2016- 02364582 to PB | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A. | es |
dc.relation.ispartof | Frontiers In Aging Neuroscience, 13 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Sex differences | es |
dc.subject | Sexual dimorphism | es |
dc.subject | Aging | es |
dc.subject | Healthy individuals | es |
dc.subject | Magnetic resonance imaging | es |
dc.title | Sexual regional dimorphism of post-adolescent and middle age brain maturation. A multi-center 3T MRI study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psiquiatría | es |
dc.relation.projectID | GR-2018-12367789 to EM | es |
dc.relation.projectID | RF-2016- 02364582 to PB | es |
dc.relation.publisherversion | file:///C:/Users/user/Downloads/fnagi-13-622054.pdf | es |
dc.identifier.doi | 10.3389/fnagi.2021.622054 | es |
dc.journaltitle | Frontiers In Aging Neuroscience | es |
dc.publication.volumen | 13 | es |