dc.creator | Garrido, P. | es |
dc.creator | Hladun, R. | es |
dc.creator | Álava Casado, Enrique de | es |
dc.creator | Álvarez, R. | es |
dc.creator | Bautista, F. | es |
dc.creator | López-Ríos, F. | es |
dc.creator | Colomer, R. | es |
dc.creator | Rojo, F. | es |
dc.date.accessioned | 2022-09-29T11:43:17Z | |
dc.date.available | 2022-09-29T11:43:17Z | |
dc.date.issued | 2021-02-23 | |
dc.identifier.citation | Garrido, P., Hladun, R., Álava Casado, E.d., Álvarez, R., Bautista, F., López-Ríos, F.,...,Rojo, F. (2021). Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours. Clinical & Translational Oncology, 23 (8), 1529-1541. | |
dc.identifier.issn | 1699-3055 | es |
dc.identifier.issn | 1699-048X | es |
dc.identifier.uri | https://hdl.handle.net/11441/137471 | |
dc.description.abstract | The recent identification of rearrangements of neurotrophic tyrosine receptor kinase (NTRK) genes and the development of
specific fusion protein inhibitors, such as larotrectinib and entrectinib, have revolutionised the diagnostic and clinical manage-
ment of patients presenting with tumours with these alterations. Tumours that harbour NTRK fusions are found in both adults
and children; and they are either rare tumours with common NTRK fusions that may be diagnostic, or more prevalent tumours
with rare NTRK fusions. To assess currently available evidence on this matter, three key Spanish medical societies (the Span-
ish Society of Medical Oncology (SEOM), the Spanish Society of Pathological Anatomy (SEAP), and the Spanish Society of
Paediatric Haematology and Oncology (SEHOP) have brought together a group of experts to develop a consensus document that
includes guidelines on the diagnostic, clinical, and therapeutic aspects of NTRK-fusion tumours. This document also discusses
the challenges related to the routine detection of these genetic alterations in a mostly public Health Care System. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer | es |
dc.relation.ispartof | Clinical & Translational Oncology, 23 (8), 1529-1541. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Gene fusions | es |
dc.subject | Molecular oncology | es |
dc.subject | Mutations | es |
dc.subject | Neoplasm | es |
dc.subject | Target therapies | es |
dc.title | Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s12094-021-02558-0 | es |
dc.identifier.doi | 10.1007/s12094-021-02558-0 | es |
dc.journaltitle | Clinical & Translational Oncology | es |
dc.publication.volumen | 23 | es |
dc.publication.issue | 8 | es |
dc.publication.initialPage | 1529 | es |
dc.publication.endPage | 1541 | es |