Artículo
Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia
Autor/es | Andreu Bernabeu, Álvaro
Díaz Caneja, Covadonga M. Costas, Javier De Hoyos, Lucía Stella, Carol Gurriarán, Xaquín Crespo Facorro, Benedicto González Peñas, Javier |
Departamento | Universidad de Sevilla. Departamento de Psiquiatría |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-09-28 |
Publicado en |
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Resumen | Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control ... Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia. |
Cita | Andreu Bernabeu, Á., Díaz Caneja, C.M., Costas, J., De Hoyos, L., Stella, C., Gurriarán, X.,...,González Peñas, J. (2022). Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia. Nature Communications, 13 (1), 1-11. |
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