dc.creator | Dima, Danai | es |
dc.creator | Modabbernia, Amirhossein | es |
dc.creator | Papachristou, Efstathios | es |
dc.creator | Doucet, Gaelle E. | es |
dc.creator | Agartz, Ingrid | es |
dc.creator | Aghajani, Moji | es |
dc.creator | Crespo Facorro, Benedicto | es |
dc.creator | Klein, Marieke | es |
dc.date.accessioned | 2022-09-28T15:29:03Z | |
dc.date.available | 2022-09-28T15:29:03Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Dima, D., Modabbernia, A., Papachristou, E., Doucet, G.E., Agartz, I., Aghajani, M.,...,Klein, M. (2021). Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping, 43 (1), 452-469. | |
dc.identifier.issn | 1065-9471 (impreso) | es |
dc.identifier.issn | 1097-0193 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/137444 | |
dc.description.abstract | Age has a major effect on brain volume. However, the normative studies available are
constrained by small sample sizes, restricted age coverage and significant methodological
variability. These limitations introduce inconsistencies and may obscure or distort
the lifespan trajectories of brain morphometry. In response, we capitalized on the
resources of the Enhancing Neuroimaging Genetics through Meta-Analysis
(ENIGMA) Consortium to examine age-related trajectories inferred from crosssectional
measures of the ventricles, the basal ganglia (caudate, putamen, pallidum,
and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic
resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical
structure volumes were at their maximum value early in life. The volume of
the basal ganglia showed a monotonic negative association with age thereafter; there
was no significant association between age and the volumes of the thalamus, amygdala
and the hippocampus (with some degree of decline in thalamus) until the sixth
decade of life after which they also showed a steep negative association with age.
The lateral ventricles showed continuous enlargement throughout the lifespan. Age
was positively associated with inter-individual variability in the hippocampus and
amygdala and the lateral ventricles. These results were robust to potential confounders
and could be used to examine the functional significance of deviations from
typical age-related morphometric patterns. | es |
dc.format | application/pdf | es |
dc.format.extent | 18 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | Human Brain Mapping, 43 (1), 452-469. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Brain morphometry | es |
dc.subject | ENIGMA | es |
dc.subject | Longitudinal trajectories | es |
dc.subject | Multisite | es |
dc.title | Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psiquiatría | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/hbm.25320 | es |
dc.identifier.doi | 10.1002/hbm.25320 | es |
dc.journaltitle | Human Brain Mapping | es |
dc.publication.volumen | 43 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 452 | es |
dc.publication.endPage | 469 | es |