dc.creator | Vázquez-Bourgon, Javier | es |
dc.creator | Mayoral-van Son, Jaqueline | es |
dc.creator | Gómez-Revuelta, Marcos | es |
dc.creator | Juncal-Ruiz, María | es |
dc.creator | Ortiz García de la Foz, Víctor | es |
dc.creator | Tordesillas-Gutiérrez, Diana | es |
dc.creator | Ayesa-Arriola, Rosa | es |
dc.creator | Bioque, Miquel | es |
dc.creator | Crespo Facorro, Benedicto | es |
dc.date.accessioned | 2022-09-27T15:03:19Z | |
dc.date.available | 2022-09-27T15:03:19Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Vázquez-Bourgon, J., Mayoral-van Son, J., Gómez-Revuelta, M., Juncal-Ruiz, M., Ortiz-García de la Foz, V., Tordesillas-Gutiérrez, D.,...,Crespo Facorro, B. (2021). Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort. International Journal of Neuropsychopharmacology, 24 (1) | |
dc.identifier.issn | 1461-1457 | es |
dc.identifier.issn | 1469-5111 (electrónica) | es |
dc.identifier.uri | https://hdl.handle.net/11441/137406 | |
dc.description.abstract | Background: Patients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic
disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a
positive impact on weight in schizophrenia. The aim of this study was to evaluate the effect of treatment discontinuation on
weight and metabolic changes in a FEP cohort.
Methods: A total of 209 FEP patients and 57 healthy controls were evaluated at study entry and prospectively at 10-year
follow-up. Anthropometric measures and, clinical, metabolic, and sociodemographic data were collected.
Results: Patients discontinuing antipsychotic treatment presented a significantly lower increase in weight and better
metabolic parameter results than those still on antipsychotic treatment at 10-year follow-up.
Conclusions: Treatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients;
however, this effect was not sufficient to reaching a complete reversal to normal levels. | es |
dc.description.sponsorship | Instituto de Salud Carlos III, España | es |
dc.format | application/pdf | es |
dc.format.extent | 7 p. | es |
dc.language.iso | eng | es |
dc.publisher | CAMBRIDGE UNIV. PRESS | es |
dc.relation.ispartof | International Journal of Neuropsychopharmacology, 24 (1) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Treatment discontinuation | es |
dc.subject | Lipid metabolism | es |
dc.subject | Weight gain | es |
dc.subject | Medication-naïve | es |
dc.subject | Second-generation antipsychotic | es |
dc.title | Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psiquiatría | es |
dc.relation.projectID | PI020499 | es |
dc.relation.projectID | PI050427 | es |
dc.relation.projectID | PI060507 | es |
dc.relation.publisherversion | https://academic.oup.com/ijnp/article/24/1/1/5897000 | es |
dc.identifier.doi | 10.1093/ijnp/pyaa066 | es |
dc.journaltitle | International Journal of Neuropsychopharmacology | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 1 | es |