dc.creator | Koelsche, Christian | es |
dc.creator | Schrimpf, Daniel | es |
dc.creator | Stichel, Damian | es |
dc.creator | Sill, Martin | es |
dc.creator | Sahm, Felix | es |
dc.creator | Reuss, David E. | es |
dc.creator | Romero Pérez, Laura | es |
dc.creator | Álava Casado, Enrique de | es |
dc.creator | Idoate Gastearena, Miguel Ángel | es |
dc.creator | Hohenberger, Peter | es |
dc.date.accessioned | 2022-09-19T15:50:33Z | |
dc.date.available | 2022-09-19T15:50:33Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Koelsche, C., Schrimpf, D., Stichel, D., Sill, M., Sahm, F., Reuss, D.E.,...,Hohenberger, P. (2021). Sarcoma classification by DNA methylation profiling. Nature Communications, 21 (1) | |
dc.identifier.issn | 2041-1723 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137211 | |
dc.description.abstract | Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some entities
lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened
with a high inter-observer variability and misclassification rate. Here, we demonstrate classification
of soft tissue and bone tumours using a machine learning classifier algorithm based
on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset
of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62
tumour methylation classes constituting a broad range of soft tissue and bone sarcoma
subtypes across the entire age spectrum. The performance is validated in a cohort of
428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our
results demonstrate the potential of the DNA methylation-based sarcoma classification for
research and future diagnostic applications. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Ggroup | es |
dc.relation.ispartof | Nature Communications, 21 (1) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Sarcoma | es |
dc.subject | DNA methylation | es |
dc.title | Sarcoma classification by DNA methylation profiling | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41467-020-20603-4 | es |
dc.identifier.doi | 10.1038/s41467-020-20603-4 | es |
dc.journaltitle | Nature Communications | es |
dc.publication.volumen | 21 | es |
dc.publication.issue | 1 | es |