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dc.creatorUrbano Gámez, Jesús Davides
dc.creatorCasañas, Juan Josées
dc.creatorBenito, Itziares
dc.creatorMontesinos, María Luzes
dc.date.accessioned2022-09-07T15:43:35Z
dc.date.available2022-09-07T15:43:35Z
dc.date.issued2021
dc.identifier.citationUrbano Gámez, J.D., Casañas, J.J., Benito, I. y Montesinos, M.L. (2021). Prenatal treatment with rapamycin restores enhanced hippocampal mGluR‑LTD and mushroom spine size in a Down’s syndrome mouse model. Molecular Brain, 14 (1), Article number 84.
dc.identifier.issn1756-6606es
dc.identifier.urihttps://hdl.handle.net/11441/136863
dc.descriptionArticle number 84es
dc.description.abstractDown syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent memory defcits. We have previously reported hippocampal mTOR (mammalian target of rapamycin) hyperactiva‑ tion, and related plasticity as well as memory defcits in Ts1Cje mice, a DS experimental model. Here we character‑ ize the proteome of hippocampal synaptoneurosomes (SNs) from these mice, and found a predicted alteration of synaptic plasticity pathways, including long term depression (LTD). Accordingly, mGluR-LTD (metabotropic Glutamate Receptor-LTD) is enhanced in the hippocampus of Ts1Cje mice and this is correlated with an increased proportion of a particular category of mushroom spines in hippocampal pyramidal neurons. Remarkably, prenatal treatment of these mice with rapamycin has a positive pharmacological efect on both phenotypes, supporting the therapeutic potential of rapamycin/rapalogs for DS intellectual disabilityes
dc.description.sponsorshipJunta de Andalucía (España) P12-CTS-1818es
dc.description.sponsorshipMinisterio de Economía, Industria y Competitividad (España) SAF2015-65032-Res
dc.formatapplication/pdfes
dc.format.extent16 p.es
dc.language.isoenges
dc.publisherBioMed Central Ltdes
dc.relation.ispartofMolecular Brain, 14 (1), Article number 84.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmGluR-LTDes
dc.subjectmTORes
dc.subjectDendritic spineses
dc.subjectProteomicses
dc.subjectDown syndromees
dc.subjectSynaptoneurosomeses
dc.subjectTrisomy 21es
dc.titlePrenatal treatment with rapamycin restores enhanced hippocampal mGluR‑LTD and mushroom spine size in a Down’s syndrome mouse modeles
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Ingeniería Eléctricaes
dc.relation.projectIDP12-CTS-1818es
dc.relation.projectIDSAF2015-65032-Res
dc.relation.publisherversionhttps://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00795-6es
dc.identifier.doi10.1186/s13041-021-00795-6es
dc.journaltitleMolecular Braines
dc.publication.volumen14es
dc.publication.issue1es
dc.publication.initialPageArticle number 84es
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)es
dc.contributor.funderFondation Jérôme Lejeune (Francia)es

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