dc.creator | Urbano Gámez, Jesús David | es |
dc.creator | Casañas, Juan José | es |
dc.creator | Benito, Itziar | es |
dc.creator | Montesinos, María Luz | es |
dc.date.accessioned | 2022-09-07T15:43:35Z | |
dc.date.available | 2022-09-07T15:43:35Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Urbano Gámez, J.D., Casañas, J.J., Benito, I. y Montesinos, M.L. (2021). Prenatal treatment with rapamycin restores enhanced hippocampal mGluR‑LTD and mushroom spine size in a Down’s syndrome mouse model. Molecular Brain, 14 (1), Article number 84. | |
dc.identifier.issn | 1756-6606 | es |
dc.identifier.uri | https://hdl.handle.net/11441/136863 | |
dc.description | Article number 84 | es |
dc.description.abstract | Down syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent
memory defcits. We have previously reported hippocampal mTOR (mammalian target of rapamycin) hyperactiva‑
tion, and related plasticity as well as memory defcits in Ts1Cje mice, a DS experimental model. Here we character‑
ize the proteome of hippocampal synaptoneurosomes (SNs) from these mice, and found a predicted alteration of
synaptic plasticity pathways, including long term depression (LTD). Accordingly, mGluR-LTD (metabotropic Glutamate
Receptor-LTD) is enhanced in the hippocampus of Ts1Cje mice and this is correlated with an increased proportion of a
particular category of mushroom spines in hippocampal pyramidal neurons. Remarkably, prenatal treatment of these
mice with rapamycin has a positive pharmacological efect on both phenotypes, supporting the therapeutic potential
of rapamycin/rapalogs for DS intellectual disability | es |
dc.description.sponsorship | Junta de Andalucía (España) P12-CTS-1818 | es |
dc.description.sponsorship | Ministerio de Economía, Industria y Competitividad (España) SAF2015-65032-R | es |
dc.format | application/pdf | es |
dc.format.extent | 16 p. | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central Ltd | es |
dc.relation.ispartof | Molecular Brain, 14 (1), Article number 84. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | mGluR-LTD | es |
dc.subject | mTOR | es |
dc.subject | Dendritic spines | es |
dc.subject | Proteomics | es |
dc.subject | Down syndrome | es |
dc.subject | Synaptoneurosomes | es |
dc.subject | Trisomy 21 | es |
dc.title | Prenatal treatment with rapamycin restores enhanced hippocampal mGluR‑LTD and mushroom spine size in a Down’s syndrome mouse model | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería Eléctrica | es |
dc.relation.projectID | P12-CTS-1818 | es |
dc.relation.projectID | SAF2015-65032-R | es |
dc.relation.publisherversion | https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00795-6 | es |
dc.identifier.doi | 10.1186/s13041-021-00795-6 | es |
dc.journaltitle | Molecular Brain | es |
dc.publication.volumen | 14 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | Article number 84 | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Fondation Jérôme Lejeune (Francia) | es |