dc.creator | Laseca, Nora | es |
dc.creator | Molina, Antonio | es |
dc.creator | Ramón, Manuel | es |
dc.creator | Valera Córdoba, María Mercedes | es |
dc.creator | Azcona, Florencia | es |
dc.creator | Encina, Ana | es |
dc.creator | Demyda-Peyrás, Sebastián | es |
dc.date.accessioned | 2022-07-25T10:20:16Z | |
dc.date.available | 2022-07-25T10:20:16Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Laseca, N., Molina, A., Ramón, M., Valera Córdoba, M.M., Azcona, F., Encina, A. y Demyda-Peyrás, S. (2022). Fine-Scale Analysis of Runs of Homozygosity Islands Affecting Fertility in Mares. Frontiers in Veterinary Science, 2022 (9), 1 p.-9 p.. | |
dc.identifier.issn | 2297-1769 | es |
dc.identifier.uri | https://hdl.handle.net/11441/135752 | |
dc.description | Nº Artículo 754028 | es |
dc.description.abstract | The loss of genetic variability in livestock populations bred under strict selection
processes is a growing concern, as it may lead to increased inbreeding values and
lower fertility, as a consequence of the “inbreeding depression” effect. This is particularly
important in horses, where inbreeding levels tend to rise as individuals become more
and more closely related. In this study, we evaluated the effect of increased inbreeding
levels on mare fertility by combining an SNP-based genomic approach using runs of
homozygosity and the estimation of genetic breeding values for reproductive traits in a
large population of Pura Raza Española mares. Our results showed a negative correlation
between whole-genome homozygosity and fertility estimated breeding values (EBVs) at
the genome level (ρ = −0.144). However, the analysis at chromosome level revealed
a wide variability, with some chromosomes showing higher correlations than others.
Interestingly, the correlation was stronger (−0.241) when we repeated the analysis in
a reduced dataset including the 10% most and least fertile individuals, where the latter
showed an increase in average inbreeding values (FROH) of around 30%. We also found
41 genomic regions (ROHi, runs of homozygosity islands) where homozygosity increased
100-fold, 13 of which were significantly associated with fertility after cross-validation.
These regions encompassed 17 candidate genes previously related to oocyte and
embryo development in several species. Overall, we demonstrated the relationship
between increased homozygosis at the genomic level and fertility in mares. Our findings
may help to deal with the occurrence of inbreeding depression, as well as further our
understanding of the mechanisms underlying fertility in mares. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A | es |
dc.relation.ispartof | Frontiers in Veterinary Science, 2022 (9), 1 p.-9 p.. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Runs of homozygosity | es |
dc.subject | Genomics | es |
dc.subject | Reproductive efficiency | es |
dc.subject | Mares | es |
dc.subject | Inbreeding | es |
dc.subject | SNP | es |
dc.subject | Fertility | es |
dc.subject | ROH | es |
dc.title | Fine-Scale Analysis of Runs of Homozygosity Islands Affecting Fertility in Mares | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Agronomía | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fvets.2022.754028 | es |
dc.identifier.doi | 10.3389/fvets.2022.754028 | es |
dc.contributor.group | Universidad de Sevilla. AGR273: Nuevas Tecnologías de Mejora Animal y de Sus Sistemas Productivos . | es |
dc.journaltitle | Frontiers in Veterinary Science | es |
dc.publication.volumen | 2022 (9) | es |
dc.publication.initialPage | 1 p. | es |
dc.publication.endPage | 9 p. | es |
dc.identifier.sisius | 9054 | es |