Artículo
Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents
Autor/es | Caro Salazar, Carlos
Dalmases, Mariona Figuerola, Albert García-Martín, María Luisa Pernia Leal, Manuel |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Fecha de publicación | 2017 |
Fecha de depósito | 2022-07-08 |
Publicado en |
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Resumen | X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous administration of contrast agents (CAs) to better visualize soft tissues. In this work, we have ... X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous administration of contrast agents (CAs) to better visualize soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles (NP). A facile ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic acid as an anchor group resulted in highly water-soluble and monodisperse nanoparticles. These PEGylated ternary NPs were tested in vivo in mice, showing slow uptake by the mononuclear phagocyte system, long blood circulation times, low toxicity, and very good X-ray contrast, thus being promising candidates as CT contrast agents for clinical applications. |
Agencias financiadoras | Junta de Andalucía Ministerio de Economía y Competitividad (MINECO). España Generalitat de Catalunya |
Identificador del proyecto | PI2013-0559
CTQ2015-68370-P 2014 SGR 129 |
Cita | Caro Salazar, C., Dalmases, M., Figuerola, A., García-Martín, M.L. y Pernía Leal, M. (2017). Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents. Nanoscale, 9 (21), 7242-7251. https://doi.org/10.1039/C7NR01110E. |
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Highly Water-Stable Rare.pdf | 1.193Mb | [PDF] | Ver/ | |