Artículo
Scatter search-based identification of local patterns with positive and negative correlations in gene expression data
Autor/es | Nepomuceno Chamorro, Juan Antonio
Troncoso Lora, Alicia Aguilar Ruiz, Jesús Salvador |
Departamento | Universidad de Sevilla. Departamento de Lenguajes y Sistemas Informáticos |
Fecha de publicación | 2015 |
Fecha de depósito | 2022-05-27 |
Publicado en |
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Resumen | This paper presents a scatter search approach based on linear correlations among genes to find biclusters,
which include both shifting and scaling patterns and negatively correlated patterns contrarily to most ... This paper presents a scatter search approach based on linear correlations among genes to find biclusters, which include both shifting and scaling patterns and negatively correlated patterns contrarily to most of correlation-based algorithms published in the literature. The methodology established here for compari son is based on a priori biological information stored in the well-known repository Gene Ontology (GO). In particular, the three existing categories in GO, Biological Process, Cellular Components and Molecular Func tion, have been used. The performance ofthe proposed algorithm has been compared to other benchmark biclustering algorithms, specifically a group of classical biclustering algorithms and two algorithms that use correlation-based merit functions. The proposed algorithm outperforms the benchmark algorithms and finds patterns based on negative correlations. Although these patterns contain important relation ship among genes, they are not found by most of biclustering algorithms. The experimental study also shows the importance of the size in a bicluster in addition to the value of its correlation. In particular, the size of a bicluster has an influence over its enrichment in a GO term |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía Universidad Pablo de Olavide |
Identificador del proyecto | TIN2011-28956-C02-00
P12-TIC-1728 APPB813097 |
Cita | Nepomuceno Chamorro, J.A., Troncoso Lora, A. y Aguilar Ruiz, J.S. (2015). Scatter search-based identification of local patterns with positive and negative correlations in gene expression data. Applied Soft Computing, 35 (October 2015), 637-651. |
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