dc.creator | Mallén Ponce, Manuel J. | es |
dc.creator | Huertas Romera, María José | es |
dc.creator | Florencio Bellido, Francisco Javier | es |
dc.date.accessioned | 2022-04-19T15:42:14Z | |
dc.date.available | 2022-04-19T15:42:14Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Mallén Ponce, M.J., Huertas Romera, M.J. y Florencio Bellido, F.J. (2022). Exploring the Diversity of the Thioredoxin Systems in Cyanobacteria. Antioxidants, 11 (4), 654. | |
dc.identifier.issn | 2076-3921 | es |
dc.identifier.uri | https://hdl.handle.net/11441/132194 | |
dc.description.abstract | Cyanobacteria evolved the ability to perform oxygenic photosynthesis using light energy to reduce CO2 from electrons extracted from water and form nutrients. These organisms also devel-oped light-dependent redox regulation through the Trx system, formed by thioredoxins (Trxs) and thioredoxin reductases (TRs). Trxs are thiol-disulfide oxidoreductases that serve as reducing sub-strates for target enzymes involved in numerous processes such as photosynthetic CO2 fixation and stress responses. We focus on the evolutionary diversity of Trx systems in cyanobacteria and discuss their phylogenetic relationships. The study shows that most cyanobacteria contain at least one copy of each identified Trx, and TrxA is the only one present in all genomes analyzed. Ferredoxin thiore-doxin reductase (FTR) is present in all groups except Gloeobacter and Prochlorococcus, where there is a ferredoxin flavin-thioredoxin reductase (FFTR). Our data suggest that both TRs may have coex-isted in ancestral cyanobacteria together with other evolutionarily related proteins such as NTRC or DDOR, probably used against oxidative stress. Phylogenetic studies indicate that they have different evolutionary histories. As cyanobacteria diversified to occupy new habitats, some of these proteins were gradually lost in some groups. Finally, we also review the physiological relevance of redox regulation in cyanobacteria through the study of target enzymes. | es |
dc.description.sponsorship | Junta de Andalucía BIO-284 | es |
dc.format | application/pdf | es |
dc.format.extent | 19 p. | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | Antioxidants, 11 (4), 654. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cyanobacteria | es |
dc.subject | Evolution | es |
dc.subject | Metabolism | es |
dc.subject | Oxidative stress | es |
dc.subject | Redox regulation | es |
dc.subject | Thioredoxin | es |
dc.subject | Thioredoxin reductase | es |
dc.title | Exploring the Diversity of the Thioredoxin Systems in Cyanobacteria | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.projectID | PID2019-104513GB-I00/AEI/10.13039/501100011033 | es |
dc.relation.projectID | BIO-284 | es |
dc.relation.publisherversion | https://doi.org/10.3390/antiox11040654 | es |
dc.identifier.doi | 10.3390/antiox11040654 | es |
dc.journaltitle | Antioxidants | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 654 | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |