dc.creator | Domínguez García, Samuel | es |
dc.creator | Gómez Oliva, Ricardo | es |
dc.creator | Geribaldi Doldán, Noelia | es |
dc.creator | Hierro Bujalance, Carmen | es |
dc.creator | Sendra, Marta | es |
dc.creator | Ruiz, Félix A. | es |
dc.creator | Carrascal Moreno, María Livia | es |
dc.creator | Núñez Abades, Pedro Antonio | es |
dc.creator | Castro, Carmen | es |
dc.date.accessioned | 2022-04-19T09:28:07Z | |
dc.date.available | 2022-04-19T09:28:07Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Domínguez García, S., Gómez Oliva, R., Geribaldi Doldán, N., Hierro Bujalance, C., Sendra, M., Ruiz, F.A.,...,Castro, C. (2021). Effects of classical PKC activation on hippocampal neurogenesis and cognitive performance: mechanism of action. Neuropsychopharmacology, 46 (6), 1207-1219. | |
dc.identifier.issn | 0893-133X | es |
dc.identifier.issn | 1740-634X | es |
dc.identifier.uri | https://hdl.handle.net/11441/132144 | |
dc.description.abstract | Hippocampal neurogenesis has widely been linked to memory and learning performance. New neurons generated from neural
stem cells (NSC) within the dentate gyrus of the hippocampus (DG) integrate in hippocampal circuitry participating in memory
tasks. Several neurological and neuropsychiatric disorders show cognitive impairment together with a reduction in DG
neurogenesis. Growth factors secreted within the DG promote neurogenesis. Protein kinases of the protein kinase C (PKC) family
facilitate the release of several of these growth factors, highlighting the role of PKC isozymes as key target molecules for the
development of drugs that induce hippocampal neurogenesis. PKC activating diterpenes have been shown to facilitate NSC
proliferation in neurogenic niches when injected intracerebroventricularly. We show in here that long-term administration of
diterpene ER272 promotes neurogenesis in the subventricular zone and in the DG of mice, affecting neuroblasts differentiation and
neuronal maturation. A concomitant improvement in learning and spatial memory tasks performance can be observed. Insights
into the mechanism of action reveal that this compound facilitates classical PKCα activation and promotes transforming growth
factor alpha (TGFα) and, to a lesser extent, neuregulin release. Our results highlight the role of this molecule in the development of
pharmacological drugs to treat neurological and neuropsychiatric disorders associated with memory loss and a deficient
neurogenesis. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades de España (MICINN) RTI-2018-099908-B-C21 y RTI-2018-099908-B-C22 | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades de España y Fondos FEDER de la Unión Europea (MICINN/FEDER) BFU2016-75038R | es |
dc.description.sponsorship | Consejería de Economía, Conocimiento, Empresas y Universidades de la Junta de Andalucía y Fondos FEDER. FEDER-UCA18-106647 | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Neuropsychopharmacology, 46 (6), 1207-1219. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Effects of classical PKC activation on hippocampal neurogenesis and cognitive performance: mechanism of action | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.projectID | RTI-2018-099908-B-C21 | es |
dc.relation.projectID | RTI-2018-099908-B-C22 | es |
dc.relation.projectID | MICINN/FEDER BFU2016-75038R | es |
dc.relation.projectID | FEDER-UCA18-106647 | es |
dc.relation.publisherversion | https://doi.org/10.1038/s41386-020-00934-y | es |
dc.identifier.doi | 10.1038/s41386-020-00934-y | es |
dc.journaltitle | Neuropsychopharmacology | es |
dc.publication.volumen | 46 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 1207 | es |
dc.publication.endPage | 1219 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Universidad de Cádiz | es |