Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Artículo
Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review
Autor/es | Moreno Fernández, Jorge
Ochoa, Julio Ojeda Murillo, María Luisa Nogales Bueno, Fátima Carreras Sánchez, Olimpia Díaz Castro, Javier |
Departamento | Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-04-18 |
Publicado en |
|
Resumen | COVID-19, an acute respiratory disease caused by SARS-CoV-2, has rapidly become a pandemic. On the other hand, obesity is also reaching dramatic dimensions and it is a risk factor for morbidity and premature mortality. ... COVID-19, an acute respiratory disease caused by SARS-CoV-2, has rapidly become a pandemic. On the other hand, obesity is also reaching dramatic dimensions and it is a risk factor for morbidity and premature mortality. Obesity has been linked to a high risk of serious-associated complications to COVID-19, due to the increased risk of concomitant chronic diseases, which highlights the health public relevance of the topic. Obese subjects have a pro-inflammatory environment, which can further exacerbate COVID-19-induced inflammation and oxidative stress, explaining the increased risk of serious complications in these patients. Another factor that favors infection in obese patients is the high expression of ACE2 receptors in the adipose tissue. The negative impact of COVID-19 in obesity is also associated with a decrease in respiratory function, the concurrence of multiple comorbidities, a low-degree chronic inflammatory state, immunocompromised situation, and therefore a higher rate of hospitalization, mechanical ventilation, in-hospital complications such as pneumonia, and death. In this review, the link between obesity and COVID-19 was analyzed, exploring the potential common mechanisms in both diseases, with special attention to oxidative stress and inflammation, due to the crucial role of both pathways in the development of the disease. |
Cita | Moreno Fernández, J., Ochoa, J., Ojeda Murillo, M.L., Nogales Bueno, F., Carreras Sánchez, O. y Díaz Castro, J. (2022). Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review. Journal of Physiology and Biochemistry |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Infammation and oxidative ... | 908.5Kb | [PDF] | Ver/ | |