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dc.creatorBodineau, Clémentes
dc.creatorTomé, Mercedeses
dc.creatorMurdoch, Piedad del Socorroes
dc.creatorCourtois, Sarahes
dc.creatorDurán Díaz, Raúl V.es
dc.creatorSciacovelli, Marcoes
dc.date.accessioned2022-03-29T11:17:21Z
dc.date.available2022-03-29T11:17:21Z
dc.date.issued2021
dc.identifier.citationBodineau, C., Tomé, M., Murdoch, P.d.S., Courtois, S., Durán Díaz, R.V. y Sciacovelli, M. (2021). Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis. Nature Communications, 12, 4814.
dc.identifier.issn2041-1723es
dc.identifier.urihttps://hdl.handle.net/11441/131409
dc.description.abstractGlutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the bioenergetic sensor AMPK during glutamoptosis is not defined yet. Here, we show that AMPK reactivation blocks both the glutamine-dependent activation of mTORC1 and glutamoptosis in vitro and in vivo. We also show that glutamine is used for asparagine synthesis and the GABA shunt to produce ATP and to inhibit AMPK, independently of glutaminolysis. Overall, our results indicate that glutamine metabolism is connected with mTORC1 activation through two parallel pathways: an acute alpha-ketoglutarate-dependent pathway; and a secondary ATP/AMPK-dependent pathway. This dual metabolic connection between glutamine and mTORC1 must be considered for the future design of therapeutic strategies to prevent cell growth in diseases such as cancer.es
dc.description.sponsorshipUnión Europea(PGC2018-096244- B-I00, SAF2016-75442-R)es
dc.formatapplication/pdfes
dc.format.extent13 p.es
dc.language.isoenges
dc.publisherNature Researches
dc.relation.ispartofNature Communications, 12, 4814.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMetabolomicses
dc.subjectApoptosises
dc.subjectNutrient signallinges
dc.titleTwo parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosises
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.relation.projectID(PGC2018-096244- B-I00, SAF2016-75442-R)es
dc.relation.publisherversion10.1038/s41467-021-25079-4es
dc.identifier.doi10.1038/s41467-021-25079-4es
dc.journaltitleNature Communicationses
dc.publication.volumen12es
dc.publication.endPage4814es
dc.contributor.funderEuropean Uniones

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