dc.creator | Jiménez Guerrero, Rocío | es |
dc.creator | Belmonte-Fernández, Alejandro | es |
dc.creator | Flores, M. Luz | es |
dc.creator | González-Moreno, Mónica | es |
dc.creator | Romero Portillo, Francisco | es |
dc.creator | Saez, Carmen | es |
dc.date.accessioned | 2022-03-19T16:01:10Z | |
dc.date.available | 2022-03-19T16:01:10Z | |
dc.date.issued | 2021-12-31 | |
dc.identifier.citation | Jiménez Guerrero, R., Belmonte-Fernández, A., Flores, M.L., González-Moreno, M., Romero, F. y Saez, C. (2021). Wnt/β-Catenin Signaling Contributes to Paclitaxel Resistance in Bladder Cancer Cells with Cancer Stem Cell-Like Properties. International Journal of Molecular Sciences, 23 (1) | |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/131035 | |
dc.description.abstract | The Wnt/β-catenin pathway plays an important role in tumor progression and chemother apy resistance and seems to be essential for the maintenance of cancer stem cells (CSC) in several
tumor types. However, the interplay of these factors has not been fully addressed in bladder cancer.
Here, our goal was to analyze the role of the Wnt/β-catenin pathway in paclitaxel resistance and
to study the therapeutic efficacy of its inhibition in bladder cancer cells, as well as to determine its
influence in the maintenance of the CSC-like phenotype in bladder cancer. Our results show that
paclitaxel-resistant HT1197 cells have hyperactivation of the Wnt/β-catenin pathway and increased
CSC-like properties compared with paclitaxel-sensitive 5637 cells. Paclitaxel sensitivity diminishes in
5637 cells after β-catenin overexpression or when they are grown as tumorspheres, enriched for the
CSC-like phenotype. Additionally, downregulation of β-catenin or inhibition with XAV939 sensitizes
HT1197 cells to paclitaxel. Moreover, a subset of muscle-invasive bladder carcinomas shows aberrant
expression of β-catenin that associates with positive expression of the CSC marker ALDH1A1. In
conclusion, we demonstrate that Wnt/β-catenin signaling contributes to paclitaxel resistance in
bladder cancer cells with CSC-like properties. | es |
dc.description.sponsorship | Instituto de Salud Carlos III FIS-PI17/1240 | es |
dc.description.sponsorship | Instituto de Salud Carlos III FIS-PI20/1641 | es |
dc.description.sponsorship | Ministry of Economy, Industry and Competitiveness SAF2017-87358-C2-1-R and -2-R | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2020-118774RB-C21 and -C22 | es |
dc.description.sponsorship | Consejería de Salud y Familias PI-0213-2020 | es |
dc.description.sponsorship | Consejería de Salud y Familias OH-0017-2018 | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 23 (1) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Wnt/β-catenin pathway | es |
dc.subject | CSC phenotype | es |
dc.subject | Paclitaxel resistance | es |
dc.subject | Bladder cancer | es |
dc.title | Wnt/β-Catenin Signaling Contributes to Paclitaxel Resistance in Bladder Cancer Cells with Cancer Stem Cell-Like Properties | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/1/450 | es |
dc.identifier.doi | 10.3390/ijms23010450 | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 23 | es |
dc.publication.issue | 1 | es |