dc.creator | Christou, Evangelia | es |
dc.creator | Pearson, John R. | es |
dc.creator | Beltrán, Ana M. | es |
dc.creator | Fernández-Afonso, Yilian | es |
dc.creator | Gutiérrez, Lucía | es |
dc.creator | Fuente, Jesús M. de la | es |
dc.creator | Gámez, Francisco | es |
dc.creator | García-Martín, María L. | es |
dc.creator | Caro, Carlos | es |
dc.date.accessioned | 2022-03-16T07:07:50Z | |
dc.date.available | 2022-03-16T07:07:50Z | |
dc.date.issued | 2022-03 | |
dc.identifier.citation | Christou, E., Pearson, J.R., Beltrán, A.M., Fernández-Afonso, Y., Gutiérrez, L., Fuente, J.M.d.l.,...,Caro, C. (2022). Iron–Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy. Pharmaceutics, 14 (3), 636-. | |
dc.identifier.issn | 1999-4923 | es |
dc.identifier.uri | https://hdl.handle.net/11441/130832 | |
dc.description.abstract | The development of nanoplatforms prepared to perform both multimodal imaging and combined therapies in a single entity is a fast-growing field. These systems are able to improve diagnostic accuracy and therapy success. Multicomponent Nanoparticles (MCNPs), composed of iron oxide and gold, offer new opportunities for Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) diagnosis, as well as combined therapies based on Magnetic Hyperthermia (MH) and Photothermal Therapy (PT). In this work, we describe a new seed-assisted method for the synthesis of Au@Fe Nanoparticles (NPs) with a flower-like structure. For biomedical purposes, Au@Fe NPs were functionalized with a PEGylated ligand, leading to high colloidal stability. Moreover, the as-obtained Au@Fe-PEG NPs exhibited excellent features as both MRI and CT Contrast Agents (CAs), with high r2 relaxivity (60.5 mM−1⋅s−1) and X-ray attenuation properties (8.8 HU mM−1⋅HU). In addition, these nanoflowers presented considerable energy-to-heat conversion under both Alternating Magnetic Fields (AMFs) (∆T ≈ 2.5 °C) and Near-Infrared (NIR) light (∆T ≈ 17 °C). Finally, Au@Fe-PEG NPs exhibited very low cytotoxicity, confirming their potential for theranostics applications. | es |
dc.description.sponsorship | Spanish Ministry of Economy, Industry and Competitiveness CTQ2017-86655-R | es |
dc.description.sponsorship | Spanish Ministry of Science and Innovation PID2020-118448RB-C21 | es |
dc.description.sponsorship | Spanish Ministry of Science and Innovation PID2020-113108RB-I00 | es |
dc.description.sponsorship | MCIN/AEI/10.13039/501100011033 | es |
dc.description.sponsorship | Fondo Social de la DGA (grupos DGA) PGC2018-096016-B-I00 | es |
dc.description.sponsorship | Regional Ministry of Health of Andalusia OH-0026-2018 | es |
dc.description.sponsorship | Regional Ministry of Health of Andalusia PAIDI 2020. P20_00727 | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Pharmaceutics, 14 (3), 636-. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Gold–iron nanoparticles | es |
dc.subject | Nanoflowers | es |
dc.subject | MRI | es |
dc.subject | CT | es |
dc.subject | Multimodal imaging | es |
dc.subject | Photothermal therapy | es |
dc.subject | Magnetic hyperthermia | es |
dc.title | Iron–Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte | es |
dc.relation.projectID | CTQ2017-86655-R | es |
dc.relation.projectID | PID2020-118448RB-C21 | es |
dc.relation.projectID | PID2020-113108RB-I00 | es |
dc.relation.projectID | MCIN/AEI/10.13039/501100011033 | es |
dc.relation.projectID | PGC2018-096016-B-I00 | es |
dc.relation.projectID | OH-0026-2018 | es |
dc.relation.projectID | PAIDI 2020. P20_00727 | es |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/14/3/636 | es |
dc.identifier.doi | 10.3390/pharmaceutics14030636 | es |
dc.contributor.group | Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales | es |
dc.journaltitle | Pharmaceutics | es |
dc.publication.volumen | 14 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 636 | es |