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dc.creatorChristou, Evangeliaes
dc.creatorPearson, John R.es
dc.creatorBeltrán, Ana M.es
dc.creatorFernández-Afonso, Yilianes
dc.creatorGutiérrez, Lucíaes
dc.creatorFuente, Jesús M. de laes
dc.creatorGámez, Franciscoes
dc.creatorGarcía-Martín, María L.es
dc.creatorCaro, Carloses
dc.date.accessioned2022-03-16T07:07:50Z
dc.date.available2022-03-16T07:07:50Z
dc.date.issued2022-03
dc.identifier.citationChristou, E., Pearson, J.R., Beltrán, A.M., Fernández-Afonso, Y., Gutiérrez, L., Fuente, J.M.d.l.,...,Caro, C. (2022). Iron–Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy. Pharmaceutics, 14 (3), 636-.
dc.identifier.issn1999-4923es
dc.identifier.urihttps://hdl.handle.net/11441/130832
dc.description.abstractThe development of nanoplatforms prepared to perform both multimodal imaging and combined therapies in a single entity is a fast-growing field. These systems are able to improve diagnostic accuracy and therapy success. Multicomponent Nanoparticles (MCNPs), composed of iron oxide and gold, offer new opportunities for Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) diagnosis, as well as combined therapies based on Magnetic Hyperthermia (MH) and Photothermal Therapy (PT). In this work, we describe a new seed-assisted method for the synthesis of Au@Fe Nanoparticles (NPs) with a flower-like structure. For biomedical purposes, Au@Fe NPs were functionalized with a PEGylated ligand, leading to high colloidal stability. Moreover, the as-obtained Au@Fe-PEG NPs exhibited excellent features as both MRI and CT Contrast Agents (CAs), with high r2 relaxivity (60.5 mM−1⋅s−1) and X-ray attenuation properties (8.8 HU mM−1⋅HU). In addition, these nanoflowers presented considerable energy-to-heat conversion under both Alternating Magnetic Fields (AMFs) (∆T ≈ 2.5 °C) and Near-Infrared (NIR) light (∆T ≈ 17 °C). Finally, Au@Fe-PEG NPs exhibited very low cytotoxicity, confirming their potential for theranostics applications.es
dc.description.sponsorshipSpanish Ministry of Economy, Industry and Competitiveness CTQ2017-86655-Res
dc.description.sponsorshipSpanish Ministry of Science and Innovation PID2020-118448RB-C21es
dc.description.sponsorshipSpanish Ministry of Science and Innovation PID2020-113108RB-I00es
dc.description.sponsorshipMCIN/AEI/10.13039/501100011033es
dc.description.sponsorshipFondo Social de la DGA (grupos DGA) PGC2018-096016-B-I00es
dc.description.sponsorshipRegional Ministry of Health of Andalusia OH-0026-2018es
dc.description.sponsorshipRegional Ministry of Health of Andalusia PAIDI 2020. P20_00727es
dc.formatapplication/pdfes
dc.format.extent11 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofPharmaceutics, 14 (3), 636-.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGold–iron nanoparticleses
dc.subjectNanoflowerses
dc.subjectMRIes
dc.subjectCTes
dc.subjectMultimodal imaginges
dc.subjectPhotothermal therapyes
dc.subjectMagnetic hyperthermiaes
dc.titleIron–Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapyes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transportees
dc.relation.projectIDCTQ2017-86655-Res
dc.relation.projectIDPID2020-118448RB-C21es
dc.relation.projectIDPID2020-113108RB-I00es
dc.relation.projectIDMCIN/AEI/10.13039/501100011033es
dc.relation.projectIDPGC2018-096016-B-I00es
dc.relation.projectIDOH-0026-2018es
dc.relation.projectIDPAIDI 2020. P20_00727es
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/14/3/636es
dc.identifier.doi10.3390/pharmaceutics14030636es
dc.contributor.groupUniversidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materialeses
dc.journaltitlePharmaceuticses
dc.publication.volumen14es
dc.publication.issue3es
dc.publication.initialPage636es

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