Artículo
Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages
Autor/es | Cárdeno Galván, Ana
Aparicio Soto, Marina Montserrat de la Paz, Sergio Bermúdez Pulgarín, Beatriz García Muriana, Francisco José Alarcón de la Lastra Romero, Catalina |
Departamento | Universidad de Sevilla. Departamento de Farmacología Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2015 |
Fecha de depósito | 2022-03-15 |
Publicado en |
|
Resumen | Squalene is a natural triterpene consumed as an integral part of the human diet. Increasing evidence demonstrates that squalene has antioxidant, cardioprotective and anti-carcinogenic activities. Nevertheless, its ... Squalene is a natural triterpene consumed as an integral part of the human diet. Increasing evidence demonstrates that squalene has antioxidant, cardioprotective and anti-carcinogenic activities. Nevertheless, its anti-inflammatory properties remain unclear. The effects of squalene on lipopolysaccharide (LPS)-mediated inflammatory response in murine macrophages and human monocytes and neutrophils were investigated. Squalene reduced intracellular levels of ROS, nitrites, cytokines (TNF-α, IL-1β, IL-6 and IFN-γ) and pro-inflammatory enzymes (iNOS, COX-2 and MPO), including a decreased expression of TLR4 and key proteins for signalling pathways mediated by NF-κB (IκBα), MAPKs (JNK) and MMPs (1, 3 and 9). In addition, squalene enhanced expression levels of anti-inflammatory enzymes (HO-1) and transcription factors (Nrf2 and PPARγ). This study establishes that squalene has significant potential for management of inflammatory conditions characterized by an over-activation of neutrophils/monocytes/macrophages and thereby for the efficient termination of the inflammatory response. |
Identificador del proyecto | AGL2008-02475
AGL2011-26949 AGL2011-29008 P-10AGR-6609 P09-CVI-5007 |
Cita | Cárdeno Galván, A., Aparicio Soto, M., Montserrat de la Paz, S., Bermúdez Pulgarín, B., García Muriana, F.J. y Alarcón de la Lastra Romero, C. (2015). Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages. Journal of Functional Foods, 14, 779-790. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Squalene targets pro- and ... | 472.6Kb | [PDF] | Ver/ | |