Innovative compounds to battle multirresistance to antibiotics: use of pva-tannic acid nano- particles to inhibit staphylococcus pseudintermedius growth

Abstract

Antibiotic resistance is an increasing public health problem that affects to numerous pathogens, including Staphylococcus pseudintermedius, which has a high prevalence of methicillin resistance and can be transmitted to humans. The development of new compounds to prevent the appearance of antibiotic resistances and find alternatives to classic therapies is essential to health protection. The main objective of the present study is to determine whether the nanoparticles of polyvinyl alcohol and tannic acid “PVA-TA NPs” are effective to inhibit Staphylococcus pseudintermedius and can be considered as an alternative therapy. The study includes increasing concentration essays of the nanoparticles and establishes, using the determination of turbidity by refractometry that could be a useful tool to inhibit bacterial growth, resulting successful. Nonetheless, further studies to identify the underlying action mechanisms of these nano-particles are going on in our group.