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dc.creatorMuñiz Guinea, Manueles
dc.creatorRiezman, Howardes
dc.date.accessioned2022-02-11T08:44:34Z
dc.date.available2022-02-11T08:44:34Z
dc.date.issued2016
dc.identifier.citationMuñiz Guinea, M. y Riezman, H. (2016). Trafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surface. Journal of Lipid Research, 57 (3), 352-360.
dc.identifier.issn1539-7262es
dc.identifier.urihttps://hdl.handle.net/11441/129881
dc.description.abstractIn eukaryotes, many cell surface proteins are attached to the plasma membrane via a glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) receive the GPI anchor as a conserved posttranslational modification in the lumen of the endoplasmic reticulum (ER). After anchor attachment, the GPI anchor is structurally remodeled to function as a transport signal that actively triggers the delivery of GPI-APs from the ER to the plasma membrane, via the Golgi apparatus. The structure and composition of the GPI anchor confer a special mode of interaction with membranes of GPI-APs within the lumen of secretory organelles that lead them to be differentially trafficked from other secretory membrane proteins. In this review, we examine the mechanisms by which GPI-APs are selectively transported through the secretory pathway, with special focus on the recent progress made in their actively regulated export from the ER and the trans-Golgi network.es
dc.formatapplication/pdfes
dc.format.extent9 p.es
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofJournal of Lipid Research, 57 (3), 352-360.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectglycolipid anchor remodelinges
dc.subjectlipid-based sortinges
dc.subjectp24 complexes
dc.titleTrafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surfacees
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
dc.relation.publisherversionhttp://dx.doi.org/10.1194/jlr.R062760es
dc.identifier.doi10.1194/jlr.R062760es
dc.journaltitleJournal of Lipid Researches
dc.publication.volumen57es
dc.publication.issue3es
dc.publication.initialPage352es
dc.publication.endPage360es

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional