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Artículo
Trafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surface
dc.creator | Muñiz Guinea, Manuel | es |
dc.creator | Riezman, Howard | es |
dc.date.accessioned | 2022-02-11T08:44:34Z | |
dc.date.available | 2022-02-11T08:44:34Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Muñiz Guinea, M. y Riezman, H. (2016). Trafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surface. Journal of Lipid Research, 57 (3), 352-360. | |
dc.identifier.issn | 1539-7262 | es |
dc.identifier.uri | https://hdl.handle.net/11441/129881 | |
dc.description.abstract | In eukaryotes, many cell surface proteins are attached to the plasma membrane via a glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) receive the GPI anchor as a conserved posttranslational modification in the lumen of the endoplasmic reticulum (ER). After anchor attachment, the GPI anchor is structurally remodeled to function as a transport signal that actively triggers the delivery of GPI-APs from the ER to the plasma membrane, via the Golgi apparatus. The structure and composition of the GPI anchor confer a special mode of interaction with membranes of GPI-APs within the lumen of secretory organelles that lead them to be differentially trafficked from other secretory membrane proteins. In this review, we examine the mechanisms by which GPI-APs are selectively transported through the secretory pathway, with special focus on the recent progress made in their actively regulated export from the ER and the trans-Golgi network. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Journal of Lipid Research, 57 (3), 352-360. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | glycolipid anchor remodeling | es |
dc.subject | lipid-based sorting | es |
dc.subject | p24 complex | es |
dc.title | Trafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surface | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.relation.publisherversion | http://dx.doi.org/10.1194/jlr.R062760 | es |
dc.identifier.doi | 10.1194/jlr.R062760 | es |
dc.journaltitle | Journal of Lipid Research | es |
dc.publication.volumen | 57 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 352 | es |
dc.publication.endPage | 360 | es |
Ficheros | Tamaño | Formato | Ver | Descripción |
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10.1194_jlr.R062760.pdf | 712.4Kb | ![]() | Ver/ | |