Artículo
Mutation in ROBO3 Gene in Patients with Horizontal Gaze Palsy with Progressive Scoliosis Syndrome: A Systematic Review
Autor/es | Piñero Pinto, Elena
Pérez Cabezas, Verónica Tous Rivera, Cristina Sánchez González, José María Ruiz Molinero, Carmen Jiménez Rejano, José Jesús Benítez Lugo, María Luisa Sánchez González, María del Carmen |
Departamento | Universidad de Sevilla. Departamento de Fisioterapia Universidad de Sevilla. Departamento de Física de la Materia Condensada |
Fecha de publicación | 2020 |
Fecha de depósito | 2022-01-24 |
Publicado en |
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Resumen | Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare, inherited disorder characterized by a congenital absence of conjugate horizontal eye movements with progressive scoliosis developing in childhood and ... Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare, inherited disorder characterized by a congenital absence of conjugate horizontal eye movements with progressive scoliosis developing in childhood and adolescence. Mutations in the Roundabout (ROBO3) gene located on chromosome 11q23–25 are responsible for the development of horizontal gaze palsy and progressive scoliosis. However, some studies redefined the locus responsible for this pathology to a 9-cM region. This study carried out a systematic review in which 25 documents were analyzed, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. The search was made in the following electronic databases from January 1995 to October 2019: PubMed, Scopus, Web of Science, PEDRO, SPORT Discus, and CINAHL. HGPPS requires a multidisciplinary diagnostic approach, in which magnetic resonance imaging might be the first technique to suggest the diagnosis, which should be verified by an analysis of the ROBO3 gene. This is important to allow for adequate ocular follow up, apply supportive therapies to prevent the rapid progression of scoliosis, and lead to appropriate genetic counseling. |
Cita | Piñero Pinto, E., Pérez Cabezas, V., Tous Rivera, C., Sánchez González, J.M., Ruiz Molinero, C., Jiménez Rejano, J.J.,...,Sánchez González, M.d.C. (2020). Mutation in ROBO3 Gene in Patients with Horizontal Gaze Palsy with Progressive Scoliosis Syndrome: A Systematic Review. International Journal of Environmental Research and Public Health, 17 (12), 4467. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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10.3390_ijerph17124467.pdf | 6.726Mb | [PDF] | Ver/ | |