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Artículo
Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine-1 Trial)
Autor/es | Cruz Chamorro, Iván
Álvarez Sánchez, Nuria Álvarez Ríos, Ana Isabel Santos Sánchez, Guillermo Pedroche, Justo Millán, Francisco Carrera Sánchez, Cecilio Fernández Pachón, María Soledad Millán-Linares, María del Carmen Martínez López, Alicia Lardone, Patricia Judith Bejarano Hernando, Ignacio Guerrero Montávez, Juan Miguel Carrillo Vico, Antonio |
Departamento | Universidad de Sevilla. Departamento de Ingeniería Química Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2021 |
Fecha de depósito | 2021-12-16 |
Publicado en |
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Resumen | Scope: We have previously demonstrated the anti-inflammatory and antioxidant properties of in vitro administered Lupinus angustifolius protein hydrolysates (LPHs) on human peripheral blood mononuclear cells (PBMCs). This ... Scope: We have previously demonstrated the anti-inflammatory and antioxidant properties of in vitro administered Lupinus angustifolius protein hydrolysates (LPHs) on human peripheral blood mononuclear cells (PBMCs). This study aims to evaluate the safety and efficacy of a beverage containing LPHs (LPHb) on the immune, oxidative and metabolic status of healthy subjects. Methods and Results: In this open-label intervention, 33 participants daily ingest a LPHb containing 1 g LPHs for 28 days. Biochemical parameters are assayed in fasting peripheral blood and urine samples before, during (14 days) and after LPHb ingestion. Participants’ health status and the immune and antioxidant responses of PBMCs are also evaluated throughout the trial. The LPHb ingestion is safe and effective in both increasing the anti-/pro-inflammatory response of PBMCs and improving the cellular anti-oxidant capacity. LPHb also reduces the low-density lipoprotein-cholesterol (LDL-C)/high-density lipoprotein-cholesterol (HDL-C) atherogenic index. LPHb effect is particularly beneficial on decreasing not only the LDL-C/HDL-C index but also serum total cholesterol levels in the male cohort that shows the highest baseline levels of well-known cardiovascular risk factors. Conclusion: This is the first study to show the pleiotropic actions of a lupine bioactive peptides-based functional food on key steps of atherosclerosis including inflammation, oxidative stress, and cholesterol metabolism. |
Identificador del proyecto | AGL2012-40247-C02-01
AGL2012-40247- C02-02 PC-0111-2016- 0111 CTS160 RD06/0013/0001 RD12/0043/0012 |
Cita | Cruz Chamorro, I., Álvarez Sánchez, N., Álvarez Ríos, A.I., Santos Sánchez, G., Pedroche, J., Millán, F.,...,Carrillo Vico, A. (2021). Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine-1 Trial). Molecular Nutrition and Food Research, 65 (14), 2100139. |
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