dc.creator | D'Anglemont De Tassigny, Xavier | es |
dc.creator | Sirerol-Piquer, M Salomé | es |
dc.creator | Gómez-Pinedo, Ulises | es |
dc.creator | Pardal Redondo, Ricardo | es |
dc.creator | Bonilla, Sonia | es |
dc.creator | Capilla González, Vivian | es |
dc.creator | López Barneo, José | es |
dc.date.accessioned | 2021-07-14T14:45:14Z | |
dc.date.available | 2021-07-14T14:45:14Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | D'Anglemont De Tassigny, X., Sirerol-Piquer, M.S., Gómez-Pinedo, U., Pardal Redondo, R., Bonilla, S., Capilla-González, V. y López Barneo, J. (2015). Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival. Hypoxia, 2015 (3), 15-33. | |
dc.identifier.issn | 2324-1128 (electrónica) | es |
dc.identifier.uri | https://hdl.handle.net/11441/116132 | |
dc.description.abstract | Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in
patients with chronic obstructive respiratory disorders, is a common medical condition that
can produce serious neurological alterations. However, the pathogenesis of this phenomenon is
unknown. We have found that adult rodents exposed for several days/weeks to hypoxia, with an
arterial oxygen tension similar to that of chronically hypoxemic patients, manifest a partially
irreversible structural disarrangement of the subventricular neurogenic niche (subventricular
zone) characterized by displacement of neurons and myelinated axons, flattening of the ependymal cell layer, and thinning of capillary walls. Despite these abnormalities, the number of
neuronal and oligodendrocyte progenitors, neuroblasts, and neurosphere-forming cells as well
as the proliferative activity in subventricular zone was unchanged. These results suggest that
neural stem cells and their undifferentiated progeny are resistant to hypoxia. However, in vivo
and in vitro experiments indicate that severe chronic hypoxia decreases the survival of newly
generated neurons and oligodendrocytes, with damage of myelin sheaths. These findings help
explain the effects of hypoxia on adult neurogenesis and provide new perspectives on brain
responsiveness to persistent hypoxemia. | es |
dc.description.sponsorship | Instituto de Salud Carlos III (XdT, Miguel Servet grant CP12-03217 and PIE13/00004) | es |
dc.description.sponsorship | Spanish Ministry of Science and Innovation (Plan Nacional, SAF program) | es |
dc.format | application/pdf | es |
dc.format.extent | 19 p. | es |
dc.language.iso | eng | es |
dc.publisher | Dove Medical Press Ltd. | es |
dc.relation.ispartof | Hypoxia, 2015 (3), 15-33. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Neural stem cells | es |
dc.subject | Chronic hypoxemia | es |
dc.subject | Subventricular germinal niche | es |
dc.subject | Ultrastructure | es |
dc.subject | Neuronal differentiation | es |
dc.subject | Oligodendrocyte survival | es |
dc.title | Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.dovepress.com/resistance-of-subventricular-neural-stem-cells-to-chronic-hypoxemia-de-peer-reviewed-fulltext-article-HP | es |
dc.identifier.doi | 0.2147/HP.S78248 | es |
dc.journaltitle | Hypoxia | es |
dc.publication.volumen | 2015 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 15 | es |
dc.publication.endPage | 33 | es |