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Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol
Author/s | Mazzotta, Sarah
Berastegui-Cabrera, Judith Vega Holm, Margarita ![]() ![]() ![]() ![]() ![]() ![]() ![]() García Lozano, María del Rosario Carretero Ledesma, Marta Claudia Aiello, Francesca Vega Pérez, José Manuel ![]() ![]() ![]() ![]() ![]() ![]() ![]() Pachón, Jerónimo Iglesias Guerra, Fernando ![]() ![]() ![]() ![]() ![]() ![]() Sánchez Céspedes, Javier |
Department | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Publication Date | 2021 |
Deposit Date | 2021-07-09 |
Published in |
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Awards | Premio Mensual Publicación Científica Destacada de la US. Facultad de Farmacia |
Abstract | Nowadays there is not an effective drug for the treatment of infections caused by human adenovirus (HAdV) which supposes a clinical challenge, especially for paediatric and immunosuppressed patients. Here, we describe the ... Nowadays there is not an effective drug for the treatment of infections caused by human adenovirus (HAdV) which supposes a clinical challenge, especially for paediatric and immunosuppressed patients. Here, we describe the design, synthesis and biological evaluation as anti-adenovirus agents of a new library (57 compounds) of diester, monoester and triazole derivatives based on 3-amino-1,2-propanediol skeleton. Seven compounds (17, 20, 26, 34, 44, 60 and 66) were selected based on their high anti-HAdV activity at low micromolar concentration (IC50 from 2.47 to 5.75 µM) and low cytotoxicity (CC50 from 28.70 to >200 µM). In addition, our mechanistic assays revealed that compounds 20 and 44 might be targeting specifically the HAdV DNA replication process, and compound 66 would be targeting HAdV E1A mRNA transcription. For compounds 17, 20, 34 and 60, the mechanism of action seems to be associated with later steps after HAdV DNA replication. |
Funding agencies | Instituto de Salud Carlos III PI17/01055, PI18/01191 |
Project ID. | PID2019-104767RB-I00
![]() CTQ2016-78580- C2-2-R ![]() REIPI RD16/0016/0009 ![]() PI17/01055 ![]() PI18/01191 ![]() DTS17/00130 ![]() BIO2015/68990-REDT ![]() C-0059-2018 ![]() |
Citation | Mazzotta, S., Berastegui-Cabrera, J., Vega Holm, M., García Lozano, M.d.R., Carretero Ledesma, M.C., Aiello, .,...,Sánchez Céspedes, J. (2021). Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol. Bioorganic Chemistry, 114, 105095. |
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