dc.creator | Barroso, Alexia | es |
dc.creator | Santos Marcos, José A. | es |
dc.creator | Perdices López, Cecilia | es |
dc.creator | Vega Rojas, Ana | es |
dc.creator | Sánchez Garrido, Miguel Ángel | es |
dc.creator | Krylova, Yelizabeta | es |
dc.creator | Molina Abril, Helena | es |
dc.creator | Ohlsson, Claes | es |
dc.creator | Pérez Martínez, Pablo | es |
dc.creator | Poutanen, Matti | es |
dc.creator | López Miranda, José | es |
dc.creator | Tena Sempere, Manuel | es |
dc.creator | Camargo, Antonio | es |
dc.date.accessioned | 2021-06-22T10:01:20Z | |
dc.date.available | 2021-06-22T10:01:20Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Barroso, A., Santos Marcos, J.A., Perdices López, C., Vega Rojas, A., Sánchez Garrido, M.Á., Krylova, Y.,...,Camargo, A. (2020). Neonatal exposure to androgens dynamically alters gut microbiota architecture. Journal of Endocrinology, 247 (1), 69-85. | |
dc.identifier.issn | 0022-0795 | es |
dc.identifier.uri | https://hdl.handle.net/11441/114715 | |
dc.description.abstract | Gonadal steroids strongly contribute to the metabolic programming that shapes the
susceptibility to the manifestation of diseases later in life, and the effect is often sexually
dimorphic. Microbiome signatures, together with metabolic traits and sex steroid levels,
were analyzed at adulthood in neonatally androgenized female rats, and compared
with those of control male and female rats. Exposure of female rats to high doses of
androgens on early postnatal life resulted in persistent altera tions of the sex steroid
profile later on life, namely lower progesterone and higher estr adiol and estrone levels,
with no effect on endogenous androgens. Neonatally androgenized females were
heavier (10% at early adulthood and 26% at adulthood) than controls and had impaired
glucose homeostasis observed by higher AUC of glucose in GTT and ITT when subjected
to obesogenic manipulations. Androgenized female displayed overt alterations in gut
microbiota, indicated especially by higher Bacteroidetes and lower Firmicutes abundance
at early adulthood, which disappeared when animals were concurrently overfed at
adulthood. Notably, these changes in gut microbiota were related with the intestinal
expression of several miRNAs, such as miR-27a-3p, miR-29a-5p, a nd miR-100-3p.
Our results suggest that nutritional and hormonal disruption at early developmental
periods not only alters the metabolic programming of the individual later in life but
also perturbs the architecture of gut microbiota, which may interact with the host by a
cross-talk mediated by intestinal miRNAs; phenomena that may contribute to amplify the
metabolic derangement caused by obesity, as seen in neonatally androgenized
female rats. | es |
dc.format | application/pdf | es |
dc.format.extent | 17 | es |
dc.language.iso | eng | es |
dc.publisher | BioScientifica | es |
dc.relation.ispartof | Journal of Endocrinology, 247 (1), 69-85. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Gut microbiota | es |
dc.subject | Hormones | es |
dc.subject | Sex steroids | es |
dc.subject | Metabolic diseases | es |
dc.subject | Obesity | es |
dc.title | Neonatal exposure to androgens dynamically alters gut microbiota architecture | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Matemática Aplicada I (ETSII) | es |
dc.relation.publisherversion | https://joe.bioscientifica.com/view/journals/joe/247/1/JOE-20-0277.xml | es |
dc.identifier.doi | 10.1530/JOE-20-0277 | es |
dc.journaltitle | Journal of Endocrinology | es |
dc.publication.volumen | 247 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 69 | es |
dc.publication.endPage | 85 | es |