dc.creator | Santos Marcos, José A. | es |
dc.creator | Haro, Carmen | es |
dc.creator | Vega Rojas, Ana | es |
dc.creator | Alcalá Díaz, Juan Francisco | es |
dc.creator | Molina Abril, Helena | es |
dc.creator | León Acuña, Ana | es |
dc.creator | López Moreno, Javier | es |
dc.creator | Landa, Blanca B. | es |
dc.creator | Tena Sempere, Manuel | es |
dc.creator | Pérez Martínez, Pablo | es |
dc.creator | López Miranda, José | es |
dc.creator | Pérez Jiménez, Francisco | es |
dc.creator | Camargo, Antonio | es |
dc.date.accessioned | 2021-06-21T10:21:03Z | |
dc.date.available | 2021-06-21T10:21:03Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Santos Marcos, J.A., Haro, C., Vega Rojas, A., Alcalá Díaz, J.F., Molina Abril, H., León Acuña, A.,...,Camargo, A. (2019). Sex Differences in the Gut Microbiota as Potential Determinants of Gender Predisposition to Disease. Molecular Nutrition and Food Research, 63 (7) | |
dc.identifier.issn | 1613-4125 | es |
dc.identifier.uri | https://hdl.handle.net/11441/113134 | |
dc.description.abstract | Scope: Dysbiosis of gut microbiota is involved in metabolic syndrome (MetS)
development, which has a different incidence between men (M) and women
(W). The differences in gut microbiota in MetS patients are explored according
to gender, and whether consuming two healthy diets, Mediterranean (MED)
and low-fat (LF), may, over time, differentially shape the gut microbiota
dysbiosis according to gender is evaluated.
Materials and Methods: All the women from the CORDIOPREV study whose
feces samples were available and a similar number of men, matched by the
main metabolic variables (N = 246, 123 women and 123 men), and
categorized according to the presence or not of MetS are included. Gut
microbiota is analyzed at baseline and after 3 years of dietary intervention.
Results: Higher abundance of Collinsella, Alistipes, Anaerotruncus, and
Phascolarctobacterium genera is observed in MetS-W than in MetS-M,
whereas the abundance of Faecalibacterium and Prevotella genera is higher in
MetS-M than in MetS-W. Moreover, higher levels of Desulfovibrio, Roseburia,
and Holdemania are observed in men than in women after the consumption
of the LF diet.
Conclusion: The results suggest the potential involvement of differences in
gut microbiota in the unequal incidence of metabolic diseases between
genders, and a sex-dependent effect on shaping the gut microbiota according
to diet. | es |
dc.description.sponsorship | Instituto de Salud Carlos III CP14/00114 | es |
dc.description.sponsorship | Instituto de Salud Carlos III PI13/00619 | es |
dc.description.sponsorship | Instituto de Salud Carlos III PI16/01777 | es |
dc.description.sponsorship | Instituto de Salud Carlos III PIE 14/00031 | es |
dc.description.sponsorship | Instituto de Salud Carlos III PIE14/00005 | es |
dc.description.sponsorship | Secretaría de Estado de Investigación, Desarrollo e Innovación AGL2012/39615 | es |
dc.description.sponsorship | Secretaría de Estado de Investigación, Desarrollo e Innovación AGL2015-67896-P | es |
dc.description.sponsorship | Junta de Andalucía CVI-7450 | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | Molecular Nutrition and Food Research, 63 (7) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Sex Differences in the Gut Microbiota as Potential Determinants of Gender Predisposition to Disease | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Matemática Aplicada I (ETSII) | es |
dc.relation.projectID | CP14/00114 | es |
dc.relation.projectID | PI13/00619 | es |
dc.relation.projectID | PI16/01777 | es |
dc.relation.projectID | PIE 14/00031 | es |
dc.relation.projectID | PIE14/00005 | es |
dc.relation.projectID | AGL2012/39615 | es |
dc.relation.projectID | AGL2015-67896-P | es |
dc.relation.projectID | CVI-7450 | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201800870 | es |
dc.identifier.doi | 10.1002/mnfr.201800870 | es |
dc.journaltitle | Molecular Nutrition and Food Research | es |
dc.publication.volumen | 63 | es |
dc.publication.issue | 7 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | Secretaría de Estado de Investigación, Desarrollo e Innovación | es |
dc.contributor.funder | Junta de Andalucía | es |