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dc.creatorMesa Restrepo, Andreaes
dc.creatorCivantos, Anaes
dc.creatorAllain, Jean Paules
dc.creatorPatiño, Edwines
dc.creatorAlzate, Juan Fernandoes
dc.creatorBalcázar, Normanes
dc.creatorMontes, Robinsones
dc.creatorPavón Palacio, Juan Josées
dc.creatorRodríguez-Ortiz, José Antonioes
dc.creatorTorres Hernández, Yadires
dc.date.accessioned2021-06-11T11:51:08Z
dc.date.available2021-06-11T11:51:08Z
dc.date.issued2021-03
dc.identifier.citationMesa Restrepo, A., Civantos, A., Allain, J.P., Patiño, E., Alzate, J.F., Balcázar, N.,...,Torres Hernández, Y. (2021). Synergistic Effect of rhBMP‐2 Protein and Nanotextured Titanium Alloy Surface to Improve Osteogenic Implant Properties. Metals, 11 (3), 464-.
dc.identifier.issn2075-4701es
dc.identifier.urihttps://hdl.handle.net/11441/111722
dc.description.abstractOne of the major limitations during titanium (Ti) implant osseointegration is the poor cellular interactions at the biointerface. In the present study, the combined effect of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) and nanopatterned Ti6Al4V fabricated with Directed irradiation synthesis (DIS) is investigated in vitro. This environmentally-friendly plasma uses ions to create self-organized nanostructures on the surfaces. Nanocones (≈36.7 nm in DIS 80◦ ) and thinner nanowalls (≈16.5 nm in DIS 60◦ ) were fabricated depending on DIS incidence angle and observed via scanning electron microscopy. All samples have a similar crystalline structure and wettability, except for sandblasted/acid-etched (SLA) and acid-etched/anodized (Anodized) samples which are more hydrophilic. Biological results revealed that the viability and adhesion properties (vinculin expression and cell spreading) of DIS 80◦ with BMP-2 were similar to those polished with BMP-2, yet we observed more filopodia on DIS 80◦ (≈39 filopodia/cell) compared to the other samples (<30 filopodia/cell). BMP-2 increased alkaline phosphatase activity in all samples, tending to be higher in DIS 80◦ . Moreover, in the mineralization studies, DIS 80◦ with BMP-2 and Anodized with BMP-2 increased the formation of calcium deposits (>3.3 fold) compared to polished with BMP-2. Hence, this study shows there is a synergistic effect of BMP-2 and DIS surface modification in improving Ti biological properties which could be applied to Ti bone implants to treat bone disease.es
dc.description.sponsorshipMinistry of Science and Innovation of Spain PID2019-109371GB-I00es
dc.description.sponsorshipJunta de Andalucía–FEDER (Spain) US1259771es
dc.formatapplication/pdfes
dc.format.extent18 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofMetals, 11 (3), 464-.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSurface modificationes
dc.subjectBone morphogenetic proteinses
dc.subjectDirected irradiation synthesises
dc.subjectNanopatterninges
dc.subjectAdvanced biointerfaceses
dc.subjectOsseointegrationes
dc.titleSynergistic Effect of rhBMP‐2 Protein and Nanotextured Titanium Alloy Surface to Improve Osteogenic Implant Propertieses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transportees
dc.relation.projectIDPID2019-109371GB-I00es
dc.relation.projectIDUS-1259771es
dc.relation.publisherversionhttps://www.mdpi.com/2075-4701/11/3/464es
dc.identifier.doi10.3390/met11030464es
dc.contributor.groupUniversidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materialeses
idus.validador.notaThis article belongs to the Topic Scientific Advances in STEM: From Professor to Studentses
dc.journaltitleMetalses
dc.publication.volumen11es
dc.publication.issue3es
dc.publication.initialPage464es
dc.contributor.funderColciencias (Departamento Administrativo de Ciencia, Tecnología e Innovación) COL-13-2-16es

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Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional