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Mostrando ítems 1-10 de 16
Artículo
Embracing monogenic Parkinson's disease: the MJFF global genetic PD cohort
(Wiley, 2023)
ABSTRACT: Background: As gene-targeted therapies are increasingly being developed for Parkinson’s disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a ...
Artículo
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome
(Nature Publishing Group, 2023)
Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. ...
Artículo
Aberrant cortical associative plasticity associated with severe adult Tourette syndrome
(Wiley, 2015)
Background. Recent studies have shown altered cortical plasticity in adult patients with Tourette syndrome. However, the clinical significance of this finding remains elusive. Methods. Motor cortical plasticity was evaluated ...
Artículo
European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents
(Springer Berlin Heidelberg, 2018-07-07)
Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological ...
Artículo
Quantitative Intensity Harmonization of Dopamine Transporter SPECT Images Using Gamma Mixture Models
(Springer, 2018-07-09)
PURPOSE: Differences in site, device, and/or settings may cause large variations in the intensity profile of dopamine transporter (DAT) single-photon emission computed tomography (SPECT) images. However, the current ...
Artículo
Sex differences in motor and non-motor symptoms among Spanish patients with Parkinson’s disease
(MDPI, 2023)
Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the ...
Artículo
The social impact of Parkinson’s disease in Spain: Report by the Spanish Foundation for the Brain
(Elsevier, 2016)
Introduction: Understanding the social and economic impact of Parkinson’s disease is essential for resource planning and raising social awareness. Development: Researchers reviewed the data published to date on epidemiology, ...
Artículo
Effects of Two Weeks of Cerebellar Theta Burst Stimulation in Cervical Dystonia Patients
(Elsevier, 2014)
Dystonia is generally regarded as a disorder of the basal ganglia and their efferent connections to the thalamus and brainstem, but an important role of cerebellar-thalamo-cortical (CTC) circuits in the pathophysiology ...
Artículo
Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease
(Public Library of Science, 2017)
The dual syndrome hypothesis for cognitive impairment in Parkinson's disease (PD) establishes a dichotomy between a frontrostriatal dopamine-mediated syndrome, which leads to executive deficits, and a posterior cortical ...
Artículo
Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
(Elsevier, 2014)
Background: Dystonia is considered as a motor network disorder involving the dysfunction of the posterior parietal cortex, a region involved in preparing and executing reaching movements. Objective/hypothesis: We used ...