dc.creator | Sánchez Jiménez, Flora | es |
dc.creator | Pérez Pérez, Antonio | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.creator | Sánchez Margalet, Víctor | es |
dc.date.accessioned | 2021-05-27T13:10:03Z | |
dc.date.available | 2021-05-27T13:10:03Z | |
dc.date.issued | 2019-07-18 | |
dc.identifier.citation | Sánchez-Jiménez, F., Pérez Pérez, A., Cruz Merino, L.d.l. y Sánchez Margalet, V. (2019). Obesity and Breast Cancer: Role of Leptin. Frontiers In Oncology, 9 (596) | |
dc.identifier.uri | https://hdl.handle.net/11441/110902 | |
dc.description.abstract | Obesity-related breast cancer is an important threat that affects especially
post-menopausal women. The link between obesity and breast cancer seems to
be relying on the microenvironment generated at adipose tissue level, which includes
inflammatory cytokines. In addition, its association with systemic endocrine changes,
including hyperinsulinemia, increased estrogens levels, and hyperleptinemia may
be key factors for tumor development. These factors may promote tumor initiation,
tumor primary growth, tissue invasion, and metastatic progression. Although the
relationship between obesity and breast cancer is already established, the different
pathophysiological mechanisms involved are not clear. Obesity-related insulin resistance
is a well-known risk factor for breast cancer development in post-menopausal women.
However, the role of inflammation and other adipokines, especially leptin, is less studied.
Leptin, like insulin, appears to be a growth factor for breast cancer cells. There exists a
link between leptin and metabolism of estrogens and between leptin and other factors
in a more complex network. As a result, obesity-associated hyperleptinemia has been
suggested as an important mediator in the pathophysiology of breast cancer. On the
other hand, recent data on the paradoxical effect of obesity on cancer immunotherapy
efficacy has brought some controversy, since the proinflammatory effect of leptin may
help the effect of immune checkpoint inhibitors. Therefore, a better knowledge of the
molecular mechanisms that mediate leptin action may be helpful to understand the
underlying processes which link obesity to breast cancer in post-menopausal women,
as well as the possible role of leptin in the response to immunotherapy in obese patients. | es |
dc.description.sponsorship | The present work was funded by grants from the Instituto de Salud Carlos III (ISCIII), PS12/00117, and PI15/01535, funded in part by FEDER Funds, to VS-M. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Frontiers In Oncology, 9 (596) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Breast cancer | es |
dc.subject | Leptin | es |
dc.subject | Leptin receptor | es |
dc.subject | Leptin signaling | es |
dc.subject | Obesity | es |
dc.title | Obesity and Breast Cancer: Role of Leptin | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.identifier.doi | 10.3389/fonc.2019.00596 | es |
dc.journaltitle | Frontiers In Oncology | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 596 | es |