Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER): Recent submissions
Now showing items 41-60 of 185
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Article
XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine
(MDPI, 2022)Whilst avoidance of chemical modifications of DNA bases is essential to maintain genome stability, during evolution ...
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Article
VID22 counteracts G-quadruplex-induced genome instability
(Oxford University Press, 2021)Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ...
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Article
Immune signaling kinases in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of motor neurons in adults, with a median ...
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Article
Distinct responses of human peripheral blood cells to different misfolded protein oligomers
(Wiley-Blackwell, 2021)Increasing evidence indicates that peripheral immune cells play a prominent role in neurodegeneration connected to protein ...
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Chapter of Book
Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast
(Elsevier, 2021)The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ...
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Article
Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance
(Wiley-Blackwell, 2021)DNA damage tolerance relies on homologous recombination (HR) and translesion synthesis (TLS) mechanisms to fill in the ...
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Article
A CDK-regulated chromatin segregase promoting chromosome replication
(Springer Nature, 2021)The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...
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Article
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
(Springer Nature, 2021)BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...
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Article
Harmful R-loops are prevented via different cell cycle-specific mechanisms
(Springer Nature, 2021)Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ...
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Article
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
(eLife Sciences Publications, 2021)DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
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Article
White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice
(MDPI, 2021)Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to ...
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Article
Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the ...
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Article
Thyroid hormones in diabetes, cancer, and aging
(Wiley, 2020)Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and ...
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Article
Molecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellitus
(Multidisciplinary Digital Publishing Institute (MDPI), 2019)Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late ...
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Article
TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands
(Wiley-Blackwell, 2020)Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating ...
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Article
The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
(American Association for Cancer Research, 2019)R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
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Article
The need to regulate replication fork speed
(American Association for the Advancement of Science, 2017) -
Article
DNA-RNA hybrids: The risks of DNA breakage during transcription
(Springer Nature, 2017)Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...
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Article
Transcription-replication conflicts: How they occur and how they are resolved
(Springer Nature, 2016)The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...
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Article
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...