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Now showing items 51-60 of 189
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Transcription-replication conflicts: How they occur and how they are resolved
(Springer Nature, 2016)
The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, between the transcription and replication machineries. These conflicts constitute a major intrinsic ...
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TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands
(Wiley-Blackwell, 2020)
Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating the transcription of target genes. TOP2 resolves the entanglement of genomic DNA by transiently ...
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Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence
(Anatomical Society of Great Britain and Ireland, John Wiley & Sons, 2016)
Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer manifestations of age-related chronic ...
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Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis
(Impact Journals, 2017)
Oncogenic transformation triggers reprogramming of cell metabolism, as part of the tumorigenic process. However, metabolic reprogramming may also increase the sensitivity of transformed cells to microenvironmental stress, ...
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Cryopreservation of GABAergic neuronal precursors for cell-based therapy
(Public Library of Science, 2017)
Cryopreservation protocols are essential for stem cells storage in order to apply them in the clinic. Here we describe a new standardized cryopreservation protocol for GABAergic neural precursors derived from the medial ...
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Guidelines and recommendations on yeast cell death nomenclature
(Shared Science Publishers, 2018)
Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular demise. However, the ...
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Editorial: Molecular chaperones and neurodegeneration
(Frontiers Media, 2017)
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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent ...
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Commentary: Immunochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases
(Frontiers Media, 2017)
In case we needed reminding, age-related neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and motor neurone disease (MND) have two factors in common: (i) advancing age as the single ...
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PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks
(Oxford University Press, 2020)
Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage ...