Browsing Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) by Title
Now showing items 152-171 of 184
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The Nup84 complex coordinates the DNA damage response to warrant genome integrity
(Oxford University Press, 2019)DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to ...
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The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
(Ivyspring International Publisher, 2023)Prostaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, ...
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The Rad50 coiled-coil domain is indispensable for Mre11 complex functions
(Nature Publishing Group, 2011)The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage ...
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The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
(Elsevier, 2011)Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. ...
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The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
(Public Library of Science, 2017)RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence ...
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The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
(Cold Spring Harbor Laboratory Press, 2019)Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...
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The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity article
(Springer Nature [academic journals on nature.com, 2018)HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small ...
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Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy
(Frontiers Media S.A., 2020)Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of ...
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Thyroid hormones in diabetes, cancer, and aging
(Wiley, 2020)Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and ...
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Titanium Surface Characteristics Induce the Specific Reprogramming of Toll-like Receptor Signaling in Macrophages
(MDPI, 2022)Most of the research on titanium-based dental implants (Ti-discs) is focused on how they are able to stimulate the formation ...
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Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
(Elsevier, 2022)DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ...
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Topological Progression in Proliferating Epithelia Is Driven by a Unique Variation in Polygon Distribution
(Public Library of Science, 2013)Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, ...
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TOPORS, a dual E3 ubiquitin and Sumo1 ligase, interacts with 26 S protease regulatory subunit 4, encoded by the PSMC1 gene
(Public Library of Science, 2016)The significance of the ubiquitin-proteasome system (UPS) for protein degradation has been highlighted in the context of ...
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Transcription as a Threat to Genome Integrity
(Annual Reviews Inc., 2016)Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, ...
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Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
(Landes Bioscience, 2009)A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ...
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Transcription-mediated replication hindrance: a major driver of genome instability
(Cold Spring Harbor Laboratory Press, 2019)Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ...
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Transcription-replication conflicts: How they occur and how they are resolved
(Springer Nature, 2016)The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...
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Transcriptional regulation of PRPF31 gene expression by MSR1 repeat elements causes incomplete penetrance in retinitis pigmentosa
(Nature Publishing Group, 2016)PRPF31-associated retinitis pigmentosa presents a fascinating enigma: some mutation carriers are blind, while others are ...