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Now showing items 161-170 of 171
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THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy
(Public Library of Science, 2014)
Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia. Management of ammonia formation can be effective in HE treatment by ...
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Polymeric nanoparticles for drug delivery: Recent developments and future prospects
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key ...
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NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins
(Elsevier, 2018)
Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial effect on other important diseases. However, the chemical instability of SFN has hampered its clinical ...
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Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates
(Elsevier, 2013)
Oligoribonucleotide conjugates carrying apolar carbohydrates at the 5′-end and the corresponding siRNA duplexes have been prepared using phosphoramidite chemistry. All the carbohydrate-siRNA derivatives were compatible ...
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Hydrolytic degradation of D-mannitol-based polyurethanes
(Elsevier, 2018)
The capacity of redox D-mannitol-based polyurethanes to modulate the glutathione response under physiological conditions, as well as their effectiveness for sustained and site-specific drug release in the gastrointestinal ...
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Influence of the porosity and type of bioglass on the micro-mechanical and bioactive behavior of coated porous titanium substrates
(Elsevier, 2021-01)
In this study, the best equilibrium among adherence, micro-mechanical properties and coating bioactivity of bioactive glasses (45S5 and 1393) on porous titanium substrates has been explored and their potential uses for ...
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Polyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn' s Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathways
(MDPI, 2020)
Nutraceuticals include a wide variety of bioactive compounds, such as polyphenols, which have been highlighted for their remarkable health benefits. Specially, maqui berries have shown great antioxidant activity and ...
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Evaluación del desarrollo de competencias de comunicación y capacidad de análisis en alumnos del practicum de farmacia
(Universidad de Granada: Facultad de Farmacia, 2010)
El equipo de Prácticas Tuteladas de la Facultad de Farmacia de la Universidad de Sevilla, en su compromiso de adecuación al Espacio Europeo de Educación Superior del Practicum de la licenciatura, viene desarrollando desde ...
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Identifying Coordination Geometries of Metal Aquaions in Water: Application to the Case of Lanthanoid and Actinoid Hydrates
(American Chemical Society, 2016)
The angular distribution function (ADF) associated with the oxygen-metal ion-oxygen angle (OMO) of several trivalent lanthanoid and actinoid aquaions has been used to identify the most probable coordination geometry of ...