Hydrolytic degradation of D-mannitol-based polyurethanes
|Romero Azogil, Lucía
Benito Hernández, Elena María
Martínez de Ilarduya, Antxon
García Martín, María de Gracia
Galbis Pérez, Juan Antonio
|Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica
|The capacity of redox D-mannitol-based polyurethanes to modulate the glutathione response under physiological conditions, as well as their effectiveness for sustained and site-specific drug release in the gastrointestinal ...
The capacity of redox D-mannitol-based polyurethanes to modulate the glutathione response under physiological conditions, as well as their effectiveness for sustained and site-specific drug release in the gastrointestinal tract (GIT), have been demonstrated in previous studies. Based on those promising results, our attention has now been drawn towards hydrolytic degradation processes at 37 °C and different pH values, from acidic to basic conditions, as in the GIT. For that, two sets of branched and linear D-mannitol-based polyurethanes containing disulfide bonds have been synthesized, which has been possible depending on the starting D-mannitol-derived monomer. Thus 3,4-O-isopropylidene-D-mannitol, having two secondary hydroxyl groups in addition to the two primary hydroxyl groups, afforded polyurethanes with a certain degree of branching. In contrast, 2,4:3,5-di-O-isopropylidene-D-mannitol and 2,3:4,5-di-O-isopropylidene-D-mannitol, lacking secondary hydroxyl groups, led to linear polyurethanes. Removal of the O-isopropylidene protecting groups resulted in more-hydrophilic materials. As in glutathione-mediated degradation, the branched polyurethanes presented enhanced degradation under physiological conditions, proportional to the content of D-mannitol, whereas linear polyurethanes were degraded slowly, and pH 8 and 10 were required.
|Ministerio de Economía y Competitividad (MINECO). España
Junta de Andalucía
|Romero Azogil, L., Benito Hernández, E.M., Martínez de Ilarduya, A., García Martín, M.d.G. y Galbis Pérez, J.A. (2018). Hydrolytic degradation of D-mannitol-based polyurethanes. Polymer Degradation and Stability, 153, 262-271.