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Browsing Artículos (Química Orgánica y Farmacéutica) by Author "Aviñó, Anna"
Now showing items 1-7 of 7
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Article
Apolar carbohydrates as DNA capping agents
Lucas Rodríguez, Ricardo; Vengut Climent, Empar; Gómez Pinto, Irene; Aviñó, Anna; Eritja, Ramón; González, Carlos; Morales, Juan Carlos (Royal Society of Chemistry, 2012)Mono- and disaccharides have been shown to stack on top of DNA duplexes stabilizing sequences with terminal C–G base pairs. ...
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Article
Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End
Gómez Pinto, Irene; Vengut Climent, Empar; Lucas Rodríguez, Ricardo; Aviñó, Anna; Eritja, Ramón; González, Carlos; Morales, Juan Carlos (Wiley-Blackwell, 2013)Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, ...
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Glucose-nucleobase pairs within DNA: Impact of hydrophobicity, alternative linking unit and DNA polymerase nucleotide insertion studies
Vengut Climent, Empar; Peñalver, Pablo; Lucas Rodríguez, Ricardo; Gómez Pinto, Irene; Aviñó, Anna; Muro Pastor, Alicia María; Galbis Fuster, Elsa; Paz Báñez, María Violante de; Fonseca Guerra, Célia; Bickelhaupt, F. Matthias; Eritja, Ramón; González, Carlos; Morales, Juan Carlos (Royal Society of Chemistry, 2018)Recently, we studied glucose-nucleobase pairs, a binding motif found in aminoglycoside-RNA recognition. DNA duplexes with ...
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Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA
Vengut Climent, Empar; Gómez Pinto, Irene; Lucas Rodríguez, Ricardo; Peñalver, Pablo; Aviñó, Anna; Fonseca Guerra, Célia; Bickelhaupt, F. Matthias; Eritja, Ramón; González, Carlos; Morales, Juan C. (Wiley-Blackwell, 2016)Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside–RNA ...
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Article
Highly Polar Carbohydrates Stack Onto DNA Duplexes Via CH/π Interactions
Lucas Rodríguez, Ricardo; Gómez Pinto, Irene; Aviñó, Anna; Reina, Jose J.; Eritja, Ramón; González, Carlos; Morales, Juan C. (American Chemical Society, 2011)Carbohydrate-nucleic acid contacts are known to be a fundamental part of some drug-DNA recognition processes. Most of these ...
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Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations
Aviñó, Anna; Ocampo, Sandra M.; Lucas Rodríguez, Ricardo; Reina, José Juan; Morales, Juan Carlos; Perales, José Carlos; Eritja, Ramón (Springer Nature, 2011)Oligoribonucleotide conjugates and the corresponding siRNA duplexes against tumor necrosis factor carrying one, two, or ...
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Article
Synthesis, cell-surface binding, and cellular uptake of fluorescently labeled glucose-DNA conjugates with different carbohydrate presentation
Ugarte Uribe, Begoña; Pérez Rentero, Sonia; Lucas Rodríguez, Ricardo; Aviñó, Anna; Reina, José Juan; Alkorta, Itziar; Eritja, Ramón; Morales, Juan Carlos (American Chemical Society, 2010)Oligonucleotide conjugates carrying carbohydrates at the 5′-end have been prepared. Glucose, fucose, and saccharides ...