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Browsing Química Orgánica y Farmacéutica by Author "Khiar, Noureddine"
Now showing items 1-20 of 28
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Article
An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols
Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Recio Jiménez, Rocío; Alcarranza Saucedo, Manuel; Khiar, Noureddine; Fernández Fernández, Inmaculada (Wiley Online Library, 2018-03)An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin, has been developed for the enantioselective rhodium-catalysed ...
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Article
Biological Evaluation of Carbohydrate-based Aprepitant Analogs for Neuroblastoma Treatment
Valdivia Giménez, Victoria Esther; Recio Jiménez, Rocío; Lerena, Patricia; Pozo, Esther; Serrano, Rosario; Calero, Raúl; Pintado, Cristina; Pernia Leal, Manuel; Moreno Rodríguez, Nazaret; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2024)Different studies using Aprepitant, a NK1R antagonist currently used as a clinical drug for treating chemotherapy-related ...
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Article
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
Recio Jiménez, Rocío; Lerena Pérez, Patricia; Pozo Torres, Esther; Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel; Valdivia Giménez, Victoria Esther; Pernia Leal, Manuel; Mouillac, Bernard; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (American Chemical Society, 2021)NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment ...
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Article
Chiral sulfur derivatives in the allylation of acyl hydrazones: C 2-symmetric bis-sulfinamides as enhanced chiral organic promoters
Fernández Fernández, Inmaculada; Alcudia Cruz, Ana; Gori, Beatrice; Valdivia Giménez, Victoria Esther; Recio Jiménez, Rocío; García, María Victoria; Khiar, Noureddine (Royal Society of Chemistry, 2010-10)Monosulfinamides and C2-symmetric bis-sulfinamides are convenient neutral chiral promoters in the allylation of acyl ...
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PhD Thesis
Derivados quirales de azufre y de fósforo: síntesis y aplicaciones en catálisis asimétrica
Chelouan, Ahmed (2014-12-19)El trabajo presentado en esta Tesis Doctoral forma parte de un proyecto de investigación más amplio desarrollado a lo largo ...
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Presentation
Design and synthesis of supramolecular hydrogels for biomedical applications
Romero Ben, Elena; Valdivia Giménez, Victoria Esther; Khiar, Noureddine (Universidad Pablo de Olavide, 2016)Motivation: Only a few cells in the human organism keep their ability to regenerate. Hence, modern medical research intends ...
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Article
Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification
Recio Jiménez, Rocío; Vengut-Climent, Empar; Mouillac, Bernard; Orcel, Hélène; López Lázaro, Miguel; Calderón Montaño, José Manuel; Álvarez González, Eleuterio; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2017)A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide ...
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Article
DMAP-Catalysed Sulfinylation of Diacetone-D-Glucose: Improved Method for the Synthesis of Enantiopure tert-Butyl Sulfoxides and tert-Butanesulfinamide
Chelouan, Ahmed; Recio Jiménez, Rocío; Alcudia Cruz, Ana; Khiar, Noureddine; Fernández Fernández, Inmaculada (Wiley Online Library, 2014-11)An improved method for the tert-butanesulfinylation of diacetone glucose with tert-butanesulfinyl chloride is reported. ...
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Article
Enantioselective synthesis of 4-amino-3,4-dihydrocoumarins and their non-cyclic hydroxyester precursors: Biological evaluation for the treatment of glioblastoma multiforme
Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Recio Jiménez, Rocío; Moreno Rodríguez, Nazaret; Chelouan, Ahmed; Álvarez, Eleuterio; Sánchez Coronilla, Antonio; Caro Salazar, Carlos; Pearson, John R.; García-Martín, María Luisa; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2022)The stereoselective addition of ethyl acetate enolate to the C═N bond of N-tert-butylsulfinylimines has been investigated ...
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Article
Improved non-covalent biofunctionalization of multi-walled carbon nanotubes using carbohydrate amphiphiles with a butterfly-like polyaromatic tail
Assali, Mohyeddin; Pernia Leal, Manuel; Fernández Fernández, Inmaculada; Romero Gómez, Pablo; Baati, Rachid; Khiar, Noureddine (Springer, 2010)We have developed an efficient strategy for the non-covalent functionalization of multi-walled carbon nanotubes (MWCNTs) ...
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Article
Molecular bottom-up approaches for the synthesis of inorganic and hybrid nanostructures
Escudero Belmonte, Alberto; Carrillo Carrión, Carolina; Romero Ben, Elena; Franco, Ana; Rosales Barrios, Christian; Castillejos Anguiano, María del Carmen; Khiar, Noureddine (Multidisciplinary Digital Publishing Institute (MDPI), 2021)Chemical routes for the synthesis of nanostructures are fundamental in nanoscience. Among the different strategies for the ...
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Article
N -Isopropylsulfinylimines vs. N-tert -butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: An improved synthesis of enantiopure (R)- And (S)-rimantadine and the trifluoromethylated analogues
Moreno Rodríguez, Nazaret; Recio Jiménez, Rocío; Valdivia Giménez, Victoria Esther; Khiar, Noureddine; Fernández Fernández, Inmaculada (Royal Society of Chemistry, 2019-11-04)An improved fully stereoselective synthesis of both enantiomers of rimantadine and its trifluoromethylated analogues has ...
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PhD Thesis
Nanotubos de carbono biocampatibles, síntesis y aplicaciones en biomedicina
Assali, Mohyeddin (2012-01-01)Considerando todo lo comentado anteriormente, el planteamiento general de esta Tesis Doctoral ha consistido en la síntesis ...
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Article
New sulfur-phosphine ligands derived from sugars: synthesis and application in palladium-catalyzed allylic alkylation and in rhodium asymmetric hydrogenation
Khiar, Noureddine; Navas, Raquel; Álvarez González, Eleuterio; Fernández Fernández, Inmaculada (Arkat USA, 2008)An efficient route to mixed phosphine / thioglycoside ligands type IV starting from glucose pentaacetate is reported. In ...
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Article
NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins
Recio Jiménez, Rocío; Elhalem, Eleonora; Benito, Juan M.; Fernández Fernández, Inmaculada; Khiar, Noureddine (Elsevier, 2018)Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial ...
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PhD Thesis
Nuevas aplicaciones de los derivados quirales de Azufre: Organocatálisis, síntesis enantioselectiva de calciomiméticos y acoplamiento de Suzuki - Miyaura
Valdivia Giménez, Victoria Esther (2010) -
PhD Thesis
Nuevas aproximaciones modulares para la síntesis estereoselectiva de ligandos quirales bidentados y compuestos de interés farmacológico, a partir de n-terc-butilsulfiniliminas.
Borrego Sánchez de la Cuesta, Lorenzo Gabriel (2017-11-24) -
Article
Phosphinite Thioglycosides Derived from Natural D-Sugars as Useful P/S Ligands for the Synthesis of Both Enantiomers in Palladium-Catalyzed Asymmetric Substitution
Khiar, Noureddine; Suárez, Belén; Valdivia Giménez, Victoria Esther; Fernández Fernández, Inmaculada (Georg Thieme Verlag, 2005)Phosphinite thioglycosides I for which a modular synthetic approach is reported, were found highly efficient catalyst ...
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Article
Proline-coated gold nanoparticles as a highly efficient nanocatalyst for the enantioselective direct aldol reaction in water
Khiar, Noureddine; Navas, Raquel; Elhalem, Eleonora; Valdivia Giménez, Victoria Esther; Fernández Fernández, Inmaculada (Royal Society of Chemistry, 2013)Reported is an efficient approach to the synthesis of water-soluble proline-coated gold nanoparticles through a place ...
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Article
Pseudo enantiomeric mixed s/p ligands derived from carbohydrates for the 1,4-addition of phenyl boronic acid to cyclohexenone
Valdivia Giménez, Victoria Esther; Bilbao Bustinza, Nerea; Moya, Juan Francisco; Rosales Barrios, C.; Salvador, Álvaro; Recio Jiménez, Rocío; Fernández Fernández, Inmaculada; Khiar, Noureddine (Royal Society of Chemistry, 2016)The application of phosphinite-thioglycosides and phosphine-thioglycosides ligands in the Rh(I)-catalyzed 1,4-addition of ...