Buscar
Mostrando ítems 1-7 de 7
Artículo
Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
(MDPI AG, 2022)
Abstract: A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD patients and a reduced risk of progression to advanced ...
Artículo
Management of NAFLD patients with advanced fibrosis
(Wiley-Blackwell, 2021-06-21)
The prevalence of non alcoholic fatty liver disease (NAFLD) has increased to 25% in the general population and could double by 2030. Liver fibrosis is the main indicator of morbidity and mortality and recent estimations ...
Artículo
Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases
(Frontiers Media, 2021-11-24)
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi-organ involvement. This entity has ...
Artículo
Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD
(SPRINGER, 2022)
Background NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust preclinical drug development. We aimed to assess the histological response after the experimental treatment ...
Artículo
Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver
(Frontiers Media S.A., 2022)
Tissue-to-tissue crosstalk regulates organ function, according to growing data. This phenomenon is relevant for pancreatic b-cells and the liver, as both tissues are involved in glucose homeostasis and lipid metabolism. ...
Artículo
Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
(Nature Publishing Group, 2022)
The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry ...
Artículo
Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis
(Aran Ediciones S.A., 2021)
Background and aims: SARS-CoV-2 is mainly a respiratory virus that has relevant systemic effects. We assessed the impact of baseline liver function (aspartate aminotransfer ase [AST], alanine aminotransferase [ALT], ...