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Mostrando ítems 1-10 de 11
Artículo
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels (UhpT and GlpT). Glycerol is clinically used as a treatment for elevated intracranial pressure ...
Artículo
Phenotypic and molecular characterizations of carbapenem-resistant Acinetobacter baumannii isolates collected within the EURECA study
(Elsevier Science, 2021)
Multi-drug-resistant Acinetobacter baumannii isolates are key pathogens that contribute to the global bur den of antimicrobial resistance. This study aimed to investigate the phenotypic and molecular character istics of ...
Artículo
Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival
(MDPI, 2022)
Objectives: More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a global public health problem. Successive waves of infection have produced new SARS-CoV-2 variants with new mutations for which the ...
Artículo
Prevalence and transmission dynamics of Escherichia coli ST131 among contacts of infected community and hospitalized patients
(Elsevier, 2018)
Objectives: The Escherichia coli O25b-associated ST131 clonal group was recently found to be prevalent in our area as a cause of community-acquired urinary tract infections. We evaluated the transmission dynamics and ...
Artículo
Early Stepdown From Echinocandin to Fluconazole Treatment in Candidemia: A Post Hoc Analysis of Three Cohort Studies
(Oxford University Press, 2021-05-16)
Background There are no clear criteria for antifungal de-escalation after initial empirical treatments. We hypothesized that early de-escalation (ED) (within 5 days) to fluconazole is safe in fluconazole-susceptible ...
Artículo
Antibiotic use and outcome in patients with negative blood cultures, a new target population for antimicrobial stewardship interventions: A prospective multicentre cohort (NO-BACT)
(Elsevier, 2024)
Objectives: To evaluate the appropriateness of antimicrobial treatment and the risk factors for mortality in patients with negative blood cultures (BC), in order to evaluate whether this population would be a suitable target ...
Artículo
Persistence of SARS-CoV-2 Infection in Severely Immunocompromised Patients With Complete Remission B-Cell Lymphoma and Anti-CD20 Monoclonal Antibody Therapy: A Case Report of Two Cases
(Frontiers Media S.A., 2022)
Immunosuppressant conditions such as hematological malignancies increase the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It has been described in the literature that patients on anti-CD20 ...
Artículo
Effectiveness of fosfomycin trometamol as oral step-down therapy for bacteraemic urinary tract infections due to MDR Escherichia coli: a post hoc analysis of the FOREST randomized trial
(Oxford Academic, 2023)
Background Fosfomycin is a potentially attractive option as step-down therapy for bacteraemic urinary tract infections (BUTI), but available data are scarce. Our objective was to compare the effectiveness and safety of ...
Artículo
Modelling the epidemiology of Escherichia coli ST131 and the impact of interventions on the community and healthcare centres
(Cambridge University Press, 2016)
ST131 Escherichia coli is an emergent clonal group that has achieved successful worldwide spread through a combination of virulence and antimicrobial resistance. Our aim was to develop a mathematical model, based on ...
Artículo
Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study
(Elsevier, 2021)
Background The clinical presentation of COVID-19 in patients admitted to hospital is heterogeneous. We aimed to determine whether clinical phenotypes of patients with COVID-19 can be derived from clinical data, to assess ...