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Artículo
In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study
(Elsevier, 2021-05-31)
Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson’s disease (PD) without dementia. Methods: The study included ...
Artículo
A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial
(IOS Press, 2021-02-02)
Background: Safinamide modulates both dopaminergic and glutamatergic systems with positive effects on motor and non-motor symptoms of Parkinson’s disease (PD). The drug utilization study SYNAPSES was designed to investigate ...
Artículo
Predictors of Loss of Functional Independence in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group
(MDPI, 2021-09-29)
Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify ...
Artículo
Directional deep brain stimulation for Parkinson's disease: results of an international crossover study with randomized, double-blind primary endpoint
(Blackwell Publishing INC, 2021)
Objective: Published reports on directional deep brain stimulation (DBS) have been limited to small, single-center investigations. Therapeutic window (TW) is used to describe the range of stimulation amplitudes achieving ...
Artículo
Diplopia is frequent and associated with motor and non-motor severity in Parkinson’s disease: results from the COPPADIS cohort at 2-year follow-up
(MDPI, 2021)
Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare ...
Artículo
Uso de la infusión intestinal continua de levodopa-carbidopa en pacientes con enfermedad de Parkinson avanzada en España. Subanálisis por comunidades autónomas
(Elsevier, 2021-03)
Objetivos: Comparar las características de los pacientes con enfermedad de Parkinson avan- zada en tratamiento con infusión intestinal continua de levodopa-carbidopa (IICLC) y los datos de efectividad y seguridad de IICLC ...
Artículo
A genetic analysis of a Spanish population with early onset Parkinson’s disease
(Public Library Science, 2020)
Introduction Both recessive and dominant genetic forms of Parkinson’s disease have been described. The aim of this study was to assess the contribution of several genes to the pathophysiology of early onset Parkinson’s ...
Artículo
Predictors of global non-motor symptoms burden progression in Parkinson’s disease. Results from the COPPADIS cohort at 2-year follow-up
(MDPI, 2021-06-30)
Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after ...
Artículo
Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project
(MDPI, 2021-07-31)
Abstract: Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative disease worldwide. In Spain, it affects around 120.000–150.000 individuals, and its ...
Artículo
Levodopa-induced dyskinesia in Parkinson disease specifically associates with dopaminergic depletion in sensorimotor-related functional subregions of the striatum
(Lippincott, Williams & Wilkins, 2021)
Purpose: To determine whether the development of levodopa-induced dyskinesia (LID) in Parkinson disease (PD) specifically relates to dopaminergic depletion in sensorimotor-related subregions of the striatum. Methods: ...