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Artículo
Mendelian randomisation confirms the role of Y-chromosome loss in Alzheimer’s disease aetiopathogenesis in men
(MDPI, 2023)
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY ...
Artículo
Long runs of homozygosity are associated with Alzheimer’s disease
(Nature Publishing Group, 2021)
Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer’s disease ...
Artículo
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
(NATURE PUBLISHING GROUP, 2021)
ARTICLE Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk ...