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Clinical and molecular parameters associated to pneumonitis development in non-small-cell lung cancer patients receiving chemoimmunotherapy from NADIM trial
(BMC, 2021)
Background Pneumonitis (Pn) is one of the main immune-related adverse effects, having a specialimportance in lung cancer, since they share affected tissue. Despite its clinical relevance, Pn development remains an unpredictable ...
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Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry
(BIOMED CENTRAL LTD, 2023)
Background Alpha-1 antitrypsin deficiency (AATD) is a rare disease that is associated with an increased risk of pulmonary emphysema. The European AATD Research Collaboration (EARCO) international registry was founded ...
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Neumonitis química secundaria a desinfección de superficies
(Elsevier, 2021-06-15)
Presentamos el caso de una paciente de 56 anos, asmática y fumadora. Ha consultado en menos de un mes en dos ocasiones por cuadros de hiperreactividad bronquial, donde las radiografías de tórax y la reacción en cadena ...
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Pembrolizumab Plus Gemcitabine in the Subset of Triple-Negative Advanced Breast Cancer Patients in the GEICAM/2015-04 (PANGEA-Breast) Study
(MDPI, 2021-10-29)
The PANGEA-Breast trial evaluated a new chemo-immunotherapeutic combination that would synergistically induce long-term clinical benefit in HER2-negative advanced breast cancer patients. Treatment consisted of 21-day cycles ...
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MNCD: A New Tool for Classifying Parkinson’s Disease in Daily Clinical Practice
(MDPI, 2022)
Background and objective: Parkinson’s disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key ...
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Comparative Safety and Effectiveness of Ticagrelor versus Clopidogrel in Patients With Acute Coronary Syndrome: An On-Treatment Analysis From a Multicenter Registry
(Frontiers Media, 2022-05-27)
Background: The net clinical benefit of ticagrelor over clopidogrel in acute coronary syndrome (ACS) has recently been questioned by observational studies which did not account for time-dependent confounders. We aimed to ...
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Revisión de las últimas novedades en el manejo del paciente con urticaria crónica: Consenso multidisciplinar de la comunidad autónoma de Andalucía
(Elsevier España S.L., 2020)
La urticaria crónica es una enfermedad de la piel difícil de tratar que presenta un alto impacto negativo en la calidad de vida de los pacientes. La última actualización de la guía europea para el manejo del paciente con ...
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Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project
(MDPI, 2021-07-31)
Abstract: Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative disease worldwide. In Spain, it affects around 120.000–150.000 individuals, and its ...
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Combination of Tocilizumab and Steroids to Improve Mortality in Patients with Severe COVID-19 Infection: A Spanish, Multicenter, Cohort Study
(Springer, 2021)
Background: We aimed to determine the impact of tocilizumab use on severe COVID-19 (coronavirus disease 19) pneumonia mortality. Methods: We performed a multicentre retrospective cohort study in 18 tertiary hospitals ...
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Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01
(2021-09-02)
Background Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading to severe clinical course in patients infected ...