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Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions
(Nature Publishing Group, 2024)
BACKGROUND: Several studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is mostly present in hematopoietic stem cells (HSC). The present study evaluates the anti-leukaemic ...
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Extended-spectrum beta-lactamase-producing and carbapenem-resistant enterobacterales bloodstream infection after solid organ transplantation: recent trends in epidemiology and therapeutic approaches
(Wiley-Blackwell, 2022)
Background: Infections caused by multidrug-resistant gram-negative bacilli (MDR GNB), in particular extended-spectrum β-lactamase-producing (ESBL-E) and carbapenem-resistant Enterobacterales (CRE), pose a major threat ...
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Correlaciones de biomarcadores del primer trimestre con el peso fetal y con el peso materno en embarazadas con diabetes gestacional.
(Sociedad Argentina de Endocrinología y Metabolismo, 2020-12-10)
Given the obstetric and metabolic importance of Gestational Diabetes, we wanted to study the correlations ofthe first trimester biomarkers with the weight ofthe fetus at 20 weeks and with that of the mother at 28 weeks ...
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Cellular mechanisms involved in the pathogenesis of airway remodeling in chronic lung disease
(Taylor and Francis LTD, 2022)
Background: Airway epithelial cells and lung fibroblasts play an important role in the develop-ment of chronic lung disease, but the exact mechanisms responsible have not been clarified. Our objective was to investigate ...
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Budget impact of using midnight salivary cortisol in the diagnosis of hypercortisolism
(Elsevier, 2011)
Background A single midnight serum cortisol (MSC) test has been reported to possess the best sensitivity and specificity for diagnosing Cushing's syndrome (CS). However, this test requires patient hospitalization, making ...
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Spanish Society of Hematology and Hemotherapy expert consensus opinion for SARS-CoV-2 vaccination in onco-hematological patients
(Taylor & Francis LTD, 2022)
In the midst of the COVID-19 pandemic, different vaccines in front of SARS-CoV-2 have been approved and administered in different vulnerable populations. As patients with cancer were excluded from pivotal trials of ...
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A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
(2021-12-31)
Background: Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related ...
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SEOM clinical guideline for the management of malignant melanoma (2017)
(Springer Int Publ Ag, 2018)
All melanoma suspected patients must be con firmed histologically and resected. Sentinel node biopsy must be done when tumor is over 1 mm or if less with high-risk factors. Adjuvant therapy with interferon could be ...
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Do specific antimicrobial stewardship interventions have an impact on carbapenem resistance in Gramnegative bacilli? A multicentre quasi-experimental ecological study: time-trend analysis and characterization of carbapenemases
(Oxford University Press, 2021)
Background: Carbapenem-resistant Gram-negative bacilli (CR-GNB) are among the most threatening microorganisms worldwide and carbapenem use facilitates their spread. Antimicrobial stewardship programmes (ASPs) can help to ...
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Cancer – Associated Thrombosis – A Study of Cases
(2021-10)
Research shows that the presence of cancer increases the likelihood of developing venous thromboembo lism (pulmonary thromboembolism and deep vein thrombosis) from as much as fourfold up to sevenfold. It is imperative ...