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Mendelian randomisation confirms the role of Y-chromosome loss in Alzheimer’s disease aetiopathogenesis in men
(MDPI, 2023)
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY ...
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Molecular landscape and validation of new genomic classification in 2668 adult AML patients: real life data from the PETHEMA registry
(MDPI, 2023)
Next–Generation Sequencing (NGS) implementation to perform accurate diagnosis in acute myeloid leukemia (AML) represents a major challenge for molecular laboratories in terms of specialization, standardization, costs and ...
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Propuesta de nueva denominación: esteatosis hepática metabólica (EHmet)
(Arán Ediciones, S.L., 2021)
El nombre de una enfermedad no sigue ningún protocolo definido y es habitual la aceptación por parte de la comunidad científica de diversas variantes en función de las costumbres de cada lugar. Hay ejemplos de entidades ...
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First-in-human study of JNJ-63709178, a CD123/CD3 targeting antibody, in relapsed/refractory acute myeloid leukemia
(Wiley, 2022-12-23)
This study aimed to identify a recommended phase II dose and evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics, and preliminary clinical activity of JNJ-63709178, a CD123/CD3 dual-targeting antibody, ...
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Asthma mortality in Spain from 1980 to 2019. Trends and perspectives in new treatment era
(Sociedad Española de Alergología e Inmunología Clínica, 2023)
Background: Previous studies suggest that asthma mortality rates in Spain have been decreasing in recent years. However, this trend is not homogeneous across age groups. Objective: To analyze asthma mortality rates over ...
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Editorial: Regulatory T cells in graft versus host disease
(Frontiers Media, 2023-02-20)
Regulatory T cells (Tregs) are modulators of the immune system that play a key role in maintaining self-tolerance. Treg were initially identified by Sakaguchi as CD4+CD25+ T cells that have the ability to suppress autoimmune ...
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An Active Isodicentric X Chromosome in a Case of Refractory Anaemia with Ring Sideroblasts Associated with Marked Thrombocytosis
(Hindawi, 2014)
Refractory anaemia with ring sideroblasts and marked thrombocytosis (RARS-T) is a provisional entity in the World Health Organization (WHO) classification. It displays features characteristic of both myelodysplastic syndrome ...
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Prosthetic shoulder joint infection by cutibacterium acnes: does rifampin improve prognosis? a retrospective, multicenter, observational study
(MDPI, 2021-04-21)
This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes-related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. ...
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Correlation of peripheral blood biomarkers with clinical outcomes in NSCLC patients with high PD-L1 expression treated with pembrolizumab
(2021)
Background: Immune checkpoint inhibitors (ICIs) are currently the standard therapy in advanced non small cell lung cancer (NSCLC); however, there is no well-established prognostic biomarker. We investigated the relationship ...